ArticleActa physiologica (Oxford, England)2026
TTX-S/TTX-R Na
Article in Acta physiologica (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
aimTo investigate how tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-resistant (TTX-R) Na
methodsAPs were recorded by ruptured-patch current clamp in unmyelinated C-type and myelinated Ah-type neurons from isolated and sliced nodose ganglia. Voltage derivatives and displacement current phase plots were used to determine the kick-in voltage of TTX-R following TTX-S activation. Myelinated A-type neurons, which express TTX-S exclusively, served as a model for dynamic current-clamp (DCC) simulation, in which gNa0 (TTX-S) and gNa1 (TTX-R) were injected separately or in combination.
resultsVoltage derivatives and phase plots revealed a biphasic upstroke in C- and Ah-type neurons, indicating sequential TTX-S then TTX-R activation. The TTX-R kick-in voltage was more negative in Ah-type than in C-type neurons and was strongly inversely correlated with the maximal upstroke velocity. DCC faithfully reproduced both AP types; TTX-R reactivation generated the C-type repolarization hump, and AP peak was preserved through proportional gNa0/gNa1 compensation. Increasing the integrated step size of gNa1 delayed TTX-R recruitment, reduced the second Na
conclusionTTX-S and TTX-R Na
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