Evidence map›Paper›PMID 42071171›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Cognitive reserve and longitudinal changes in brain and cognition in semantic variant primary progressive aphasia.

Lauren A Grebe, Brittany T Morin, Janhavi Pillai, David Paul Galang Baquirin, Buddhika Ratnasiri, Rian Bogley, Zoe Ezzes, Lisa D Wauters, Maria Luisa Mandelli, Zachary A Miller and 8 more

Abstract read
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Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Lauren A GrebeCommunication Sciences and Disorders, St. John's University, Jamaica, New York, USA.ORCID https://orcid.org/0009-0002-6118-757X
Brittany T MorinMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
Janhavi PillaiMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
David Paul Galang BaquirinMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
Buddhika RatnasiriMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
Rian BogleyMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
Zoe EzzesMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
Lisa D WautersMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
Maria Luisa MandelliMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
Zachary A MillerMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
Boon Lead TeeMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
Jessica de LeonMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
Kaitlin B CasalettoMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
Howard J RosenMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
Maria Luisa Gorno TempiniMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
Elizabeth E GallettaDepartment of Rehabilitation Medicine, NYU Grossman School of Medicine, New York, New York, USA.
Mira GoralSpeech-Language-Hearing Sciences, The Graduate Center, City University of New York, New York, New York, USA.
Jet M J VonkMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.ORCID https://orcid.org/0000-0002-1808-8843

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
Project 2: Biomarker Analysis, Non-Genetic Risk Factors, and Their Genetic InteractionsU19AG079774 · NIA · UNIVERSITY OF PENNSYLVANIA · PI HELENA Chang CHUI, Gyungah Jun · 2023 to 2026
$39.4M
Research Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Katherine P Rankin · 2019 to 2026
$36.9M
Augmenting Nurse Support and EHR Integration for the Pragmatic Trial of the UCSF-BHAU01NS128913 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Katherine Laurel Possin · 2022 to 2026
$8.2M
An automated machine learning approach to language changes in Alzheimer’s disease and frontotemporal dementia across Latino and English-speaking populationsR01AG075775 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI, Adolfo Martin Garcia · 2023 to 2026
$7.2M
Chinese language versions of the National Alzheimer's Coordinating Center's Uniform Data Set version 4: a linguistic and cultural adaptation studyR01AG083840 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Clara Li, Boon Lead Tee · 2023 to 2026
$5.3M
Primary Progressive Aphasia: Cognition, Anatomy and ProgressionRF1NS050915 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2022 to 2022
$4.7M
The impact of bilingualism on cognitive reserve/resilience using socio-demographically and linguistically diverse populationsR01AG080469 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Suvarna Alladi, Ganesh M Babulal · 2023 to 2026
$4.0M
Dynamic Brain Imaging of Speech in Primary Progressive AphasiaR01NS100440 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI, John Francis Houde · 2017 to 2026
$3.6M
Word fluency task performance as a marker of Alzheimer’s disease in Tagalog/English bilingual speakerR01AG080396 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jessica Anne Deleon · 2023 to 2026
$3.3M
Defining trajectories of dynamic biomarkers for C9ORF72 repeat expansion carriersR01AG058233 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEE, SUZEE EURIE · 2018 to 2022
$3.2M
Training program in the neurology of language and neurodegenerative aphasiasK24DC015544 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2016 to 2025
$1.9M
Alzheimer's Association AACSFD-22-972143Alzheimer's Disease Research Center of CaliforniaNIA NIH HHS P01 AG019724NIA NIH HHS P30 AG062422NIA NIH HHS R00 AG066934NIA NIH HHS R00AG066934NIA NIH HHS R01 AG058233NIA NIH HHS R01 AG075775NIA NIH HHS R01 AG080396NIA NIH HHS R01 AG080469NIA NIH HHS R01 AG083840NIA NIH HHS U19 AG079774NIDCD NIH HHS K24 DC015544NIH HHS NIA R01AG080469NIH HHS NIDCD K24DC015544 (M.L.G.T.)NIH HHS P01AG019724 (J.D.L.)NIH HHS R01AG058233NIH HHS R01AG075775 (M.L.G.T.)NIH HHS R01AG080396 (J.D.L.)NIH HHS R01AG083840NIH HHS R01 NS100440-01NIH HHS RF1NS050915 (M.L.G.T.)NIH HHS U01NS128913NIH HHS U19AG079774NINDS NIH HHS R01 NS100440NINDS NIH HHS RF1 NS050915NINDS NIH HHS U01 NS128913NWO/ZonMw Veni Grant
6 · The paper itself

Abstract

introductionCognitive reserve (CR) refers to the brain's ability to maintain cognitive performance despite neurodegeneration. Studying CR in semantic variant primary progressive aphasia (svPPA) may clarify variability in disease progression and identify protective factors.

methodsWe examined whether education and occupational attainment-two common CR proxies-moderated relationships between gray matter brain volume and cognitive performance in 58 individuals with svPPA. Multiple linear regression models assessed baseline and longitudinal change across five semantic and non-semantic tasks.

resultsGreater brain volume related to better cognitive performance across all tasks. However, CR moderated this relationship only for semantic tasks. At baseline, higher education/occupation was linked to better semantic performance when brain volume was lower. Longitudinally, higher education/occupation was associated with faster decline in semantic performance when brain volume was lower. DISCUSSION: CR influences language performance in svPPA, suggesting its effects are domain-specific and aligned with the progression pattern of this syndrome.

Indexed as

Aphasia, Primary ProgressiveBrainCognitionCognitive ReserveAgedDisease ProgressionEducational StatusFemaleGray MatterHumansLongitudinal StudiesMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsSemanticscognitive resilienceeducationfrontotemporal dementialanguageoccupationtrajectories

Identifiers

PMID42071171
PMCPMC13135915

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.