Evidence map›Paper›PMID 42071143›Full record

ReviewAdvances in experimental medicine and biology2026

Interactomics: Dissecting Protein Networks in Living Systems.

Carlos M Farinha, Francisco Rodrigues Pinto, João A I Miranda

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Carlos M FarinhaBioISI-Biosystems & Integrative Sciences Institute & Department of Chemistry and Biochemistry, Faculty of Sciences, Universidade de Lisboa, Lisbon, Portugal. cmfarinha@fc.ul.pt.
Francisco Rodrigues PintoBioISI-Biosystems & Integrative Sciences Institute & Department of Chemistry and Biochemistry, Faculty of Sciences, Universidade de Lisboa, Lisbon, Portugal.ORCID https://orcid.org/0000-0002-4217-0054
João A I MirandaBioISI-Biosystems & Integrative Sciences Institute & Department of Chemistry and Biochemistry, Faculty of Sciences, Universidade de Lisboa, Lisbon, Portugal.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interactomics aims at identifying and characterizing in a comprehensive way the complete set of protein-protein interactions that occur within a cell, tissue, or organism. In this chapter, we cover the most relevant experimental and computational approaches that are used in the field to assess the interactome of a specific protein or of all the proteins in a defined compartment. We address their applicability as well as their advantages and disadvantages. We then describe the different databases available to researchers interested in dissecting protein-protein interactions and finally briefly summarize the several attempts that have been made to identify the human interactome, i.e., the complete set of protein interactions that occur within a human cell.

Indexed as

Protein Interaction MappingProtein Interaction MapsProteinsAnimalsComputational BiologyDatabases, ProteinHumansProtein BindingProteomicsTwo-Hybrid System TechniquesProteinsAffinity purificationInteractomeInteractomicsProtein interaction databasesProtein-protein interactionsProximity labelingYeast two-hybrid

Identifiers

PMID42071143

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.