Evidence map›Paper›PMID 42071098›Full record

ArticleScientific reports2026

Effect of pesticide exposure on liver function tests and serum cholinesterase levels among floriculture industry workers in Bahirdar, Ethiopia: a comparative cross-sectional study.

Habtamu Molla Gietie, Gobena Dedefo, Mekdes Alem, Getachew Wolde, Mohammed Aliye, Abditsion Disani, Wessene Habtu, Genet Ashebir, Edmealem Minlarg, Tilahun Bitew and 2 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Habtamu Molla GietieDepartment of Medical Laboratory Science, College of Medicine and Health Science, Debre Markos University, P.O. Box 269, Debre Markos, Ethiopia. habtamu_molla@dmu.edu.et.
Gobena DedefoDepartment of Medical Laboratory Sciences, College of Health Sciences, Addis Ababa University, P.O. Box 1176, Addis Ababa, Ethiopia.
Mekdes AlemDepartment of Medical Laboratory Sciences, College of Health Sciences, Addis Ababa University, P.O. Box 1176, Addis Ababa, Ethiopia.
Getachew WoldeDepartment of Medical Laboratory Sciences, St. Paul Hospital Millennium Medical College, P.O. Box 1271, Addis Ababa, Ethiopia.
Mohammed AliyeDepartment of Medical Laboratory Science, College of Medicine and Health Science, Werabe University, P.O. Box 1888, Werabe, Ethiopia.
Abditsion DisaniDepartment of Medical Laboratory Sciences, Institute of Health, Bule Hora University, P.O. Box 144, Bule Hora, Ethiopia.
Wessene HabtuNational References Laboratory for Clinical Chemistry, Ethiopian Public Health Institute, P.O. Box 1242, Addis Ababa, Ethiopia.
Genet AshebirNational References Laboratory for Clinical Chemistry, Ethiopian Public Health Institute, P.O. Box 1242, Addis Ababa, Ethiopia.
Edmealem MinlargDepartment of Pharmacy, College of Medicine and Health Science, Debre Markos University, P.O. Box 269, Debre Markos, Ethiopia.
Tilahun BitewDepartment of Biomedical Science, School of Medicine, Debre Markos University, P.O. Box 269, Debre Markos, Ethiopia.
Abebe EdaoDepartment of Medical Laboratory Sciences, College of Health Sciences, Addis Ababa University, P.O. Box 1176, Addis Ababa, Ethiopia.
Mistire WoldeDepartment of Medical Laboratory Sciences, College of Health Sciences, Addis Ababa University, P.O. Box 1176, Addis Ababa, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Workers in the floriculture industry are exposed to various classes of pesticides through skin contact, inhalation, and ingestion. Although many pesticides are known to exert hepatotoxic effects and inhibit serum butyrylcholinesterase (BChE), no prior studies have been conducted in Ethiopia, particularly in the Amhara region. This study aimed to assess the effects of pesticide exposure on liver function tests and BChE among floriculture workers in Bahir Dar, Ethiopia. A comparative cross-sectional study was conducted from February 8, 2025, to May 28, 2025, including 103 floriculture workers and 51 community controls from Zege town. Sociodemographic and clinical data were collected using structured questionnaires, and venous blood samples were analyzed using the Cobas 6000 analyzer. Data were entered in Epidata 4.7 and analyzed in SPSS version 27. Statistical analyses included chi-square/Fisher's exact tests, t-tests, ANCOVA, one-way ANOVA, and multivariate logistic regression, with significance set at p < 0.05. Floriculture workers had significantly higher ALT (27.71 ± 0.44 U/L vs. 22.71 ± 0.47 U/L; MD = 4.99 [95% CI: 3.72, 6.25]; p < 0.001), AST (28.46 ± 0.68 U/L vs. 20.69 ± 0.73; MD = 7.77 [95% CI: 5.98, 9.74]; P < 0.001), TBL ( 0.831 ± 0.028 mg/dL vs. 0.362 ± 0.030 mg/dL; MD = 0.47 [95% CI: 0.39, 0.55]; P < 0.001), and DBL (0.298 ± 0.012 mg/dL vs. 0.170 ± 0.021 mg/dL; MD = 0.13 [95% CI: 0.09, 0.17]; p < 0.001) compared with controls. Conversely, total protein (7.385 ± 0.058 g/dL vs. 7.624 ± 0.098 g/dL; MD = - 0.24 [95% CI: -0.46, - 0.01]; p = 0.038), albumin (4.255 ± 0.052 g/dL vs. 4.623 ± 0.088 g/dL; MD = - 0.37 [95% CI: -0.57, - 0.17]; p < 0.001), A/G ratio (1.394 ± 0.040 vs. 1.580 ± 0.067; MD = - 0.19 [95% CI: -0.34, - 0.03]; p = 0.018), and BChE (5105 ± 141 U/L vs. 6699 ± 239 U/L; MD = - 1594 [95% CI: -2142.66, - 1045.39]; p < 0.001) were significantly lower among floriculture workers compared to control. Workers with more than 10 years of exposure showed markedly elevated ALT, AST, TBL, DBL, and globulin, while reduced albumin, A/G ratio, and BChE with < 5 years and 5-10 years (p < 0.05). Overall, prolonged pesticide exposure was associated with significant alterations of liver function and BChE among floriculture workers.

Indexed as

ButyrylcholinesteraseCholinesterasesLiverOccupational ExposurePesticidesAdultCross-Sectional StudiesEthiopiaFemaleHumansLiver Function TestsMaleMiddle AgedYoung AdultButyrylcholinesteraseCholinesterasesPesticidesCholine esteraseFloricultureHorticultureLiver function

Identifiers

PMID42071098
PMCPMC13365533

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.