Evidence map›Paper›PMID 42071066›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2026

CEBPD contributes to diabetic foot ulcer progression via transcriptional regulation of CXCL10: insights from in vitro and in vivo evidence.

Qiguo Liang, Dexian Wang, Haibo Xu, Juan Yang, Qinglian Xu

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Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Qiguo LiangDepartment of Burns, Shushan District, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei City, Anhui Province, 230032, China.
Dexian WangDepartment of Burns, The First People's Hospital of Wuhu, Wuhu, China.
Haibo XuDepartment of Burns, The First People's Hospital of Wuhu, Wuhu, China.
Juan YangDepartment of Burns, The First People's Hospital of Wuhu, Wuhu, China.
Qinglian XuDepartment of Burns, Shushan District, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei City, Anhui Province, 230032, China. xuqinglian62@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic foot ulcer (DFU) is a severe complication of diabetes mellitus characterized by impaired wound healing and high amputation risk. Current treatments remain unsatisfactory, necessitating exploration of novel molecular mechanisms. The transcription factor CCAAT enhancer binding protein delta (CEBPD) regulates inflammatory responses and cellular stress pathways implicated in diabetic complications. However, its specific role and mechanism in DFU pathogenesis are poorly understood. Human umbilical vein endothelial cells (HUVECs) were exposed to high glucose (HG) to mimic diabetic conditions. C-X-C motif chemokine ligand 10 (CXCL10) and CEBPD mRNA expression were analyzed by quantitative real-time polymerase chain reaction. The protein expression of CXCL10, CEBPD, and glutathione peroxidase 4 (GPX4) was detected by western blotting assay. Cell viability was analyzed by a cell counting kit-8 assay. Cell proliferation was analyzed by a 5-ethynyl-2'-deoxyuridine assay. Cell apoptosis was detected by flow cytometry. Cell migration was analyzed by a wound-healing assay. Tube formation was analyzed by a tube formation assay. Fe

Indexed as

CCAAT-Enhancer-Binding Protein-deltaChemokine CXCL10Diabetic FootAnimalsApoptosisCell MovementCell ProliferationDisease ProgressionFemaleGene Expression RegulationHumansHuman Umbilical Vein Endothelial CellsMaleRatsRats, Sprague-DawleyTranscription, GeneticCCAAT-Enhancer-Binding Protein-deltaCEBPD protein, humanChemokine CXCL10CXCL10 protein, humanCxcl10 protein, ratCCAAT enhancer binding protein deltaC-X-C motif chemokine ligand 10Diabetic foot ulcerWound healing

Identifiers

PMID42071066

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.