Evidence map›Paper›PMID 42070993›Full record

ReviewInternational journal of laboratory hematology2026

Practical Considerations in the Implementation of Peripheral Smear Review in the Clinical Laboratory.

Olga Pozdnyakova, Lauren H Yaeger, Cara Lunn Shirai, Stephanie McFadden, Xueyan Chen, Amrom Obstfeld, Emily F Mason, Madhu M Ouseph, Jin-Yeong Han, Gina Zini and 5 more

Abstract readReview
In one paragraph

Review in International journal of laboratory hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Olga PozdnyakovaDepartment of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Lauren H YaegerBecker Medical Library, Washington University School of Medicine, Becker Medical Library, St. Louis, Missouri, USA.
Cara Lunn ShiraiDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Stephanie McFaddenSysmex America, Inc, Lincolnshire, Illinois, USA.
Xueyan ChenTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center and Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.
Amrom ObstfeldDepartment of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0009-0000-4935-7009
Emily F MasonDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Madhu M OusephDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York, USA.ORCID https://orcid.org/0000-0002-3422-1675
Jin-Yeong HanDepartment of Laboratory Medicine, Dong-A University College of Medicine and Seegene Medical Foundation, Busan, Korea.ORCID https://orcid.org/0000-0003-0280-2739
Gina ZiniSezione di Ematologia, Dipartimento di Scienze Radiologiche Ed Ematologiche, Università Cattolica del Sacro Cuore, Rome, Italy.ORCID https://orcid.org/0000-0003-0782-294X
Ben HedleyDepartment of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada.ORCID https://orcid.org/0000-0002-3751-0851
Michelle GrantGeisinger and Geisinger Commonwealth School of Medicine, Scranton, Pennsylvania, USA.
Giuseppe D'OnofrioSezione di Ematologia, Dipartimento di Scienze Radiologiche Ed Ematologiche, Università Cattolica del Sacro Cuore, Rome, Italy.
John L FraterDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID https://orcid.org/0000-0002-4614-681X
Elizabeth L CourvilleUniversity of Virginia School of Medicine/UVA Health, Charlottesville, Virginia, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Even in the era of modern automated hematology analyzers, visual peripheral blood smear (PBS) review remains an important component of peripheral blood evaluation in a subset of specimens. Despite published PBS review guidelines, including those issued 20 years ago by the International Consensus Group for Hematology Review (ICGHR), knowledge gaps remain regarding selection and implementation of PBS visual review criteria in clinical laboratories. The purpose of this article, developed by an international working group (the Peripheral Smear Review Working Group [PSRWG]), is to help bridge knowledge gaps by providing practical guidance and items for consideration. PBS review may be indicated for automated analyzer system flags, suspect flags, numerical/definitive flags, or as a component of delta checks. Examples, explanations, and suggestions for each of these categories are provided as are examples of flag modification. Validation of PBS review criteria is a multistep process that includes defining criteria for a positive finding, selecting specimens for study, choosing the slide review method, and determining the statistical approach. Pragmatic approaches and important items to consider are provided for each of these validation steps. PBS visual review workflow must be tailored to the needs of the clinical laboratory/institution. These needs may differ depending on the accrediting agency, laboratory/institutional infrastructure, and population served. A discussion of these variables is provided. In this article, we expand on the proposed ICGHR rules with a discussion of practical considerations in the implementation of PBS review.

Indexed as

Hematologic TestsLaboratories, ClinicalHumanshematology laboratorymanual smear reviewperipheral blood filmperipheral blood smearpractical considerations

Identifiers

PMID42070993
PMCPMC13555154

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.