ArticleBrain, behavior, and immunity2026
Dietary allergen promotes sex-specific leukocyte trafficking and alters the brain immune cell populations in subclinically sensitized mice.
Article in Brain, behavior, and immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Dietary allergens can affect mood and cognition in some sensitized individuals without eliciting immediate or severe physical reactions. However, if these "subclinically sensitized," allergen-tolerant individuals continue to consume offending allergens, they may be at a greater risk of chronic peripheral inflammation that affects brain function and behavior via neuroinflammation. To elucidate potential mechanisms by which immune responses to consumed allergens are communicated to the central nervous system (CNS), we investigated the accumulation of leukocytes in the brain and the trafficking of peripheral leukocytes to the CNS in our mouse model of subclinical cow's milk allergy (CMA). Male and female C57BL/6J mice were sensitized to a bovine β-lactoglobulin (BLG, Bos d 5) or the vehicle alone and subsequently placed on an allergen-containing diet for 2 weeks. The activity and cognitive function of the mice were assessed by a series of behavioral tests, and the number and phenotypes of the leukocytes in the brain were determined by flow cytometry and immunofluorescence. The frequencies of CXCR5
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