ArticleAging cell2026
Vitamin K2 Extends Lifespan by Alleviating Mitochondrial Stress via the JNK-1/SIR-2.1/DAF-16 Signaling Axis in Caenorhabditis elegans.
Article in Aging cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Article
- A novel study to calculate immune-aging from peripheral blood T lymphocyte subsets and their mitochondrial parameters in healthy Chinese subjects.Frontiers in immunology · 2026Article
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Authors and funding
13 authors.
Funding
Abstract
Vitamin K2 is a fat-soluble vitamin that has been reported to exhibit significant anti-stress activity. Anti-stress properties are considered to be closely associated with lifespan extension. Therefore, we investigated the effects of vitamin K2 on the lifespan and stress resistance of Caenorhabditis elegans, as well as the underlying mechanisms. In the present study, we found that the effects of Vitamin K2 on C. elegans are concentration-dependent. High concentrations (10 μM) of Vitamin K2 are toxic to C. elegans, whereas lower concentrations (5 μM) are beneficial. Treatment with 5 μM Vitamin K2 can extend the lifespan of C. elegans, enhance its physiological functions, protect the intestinal barrier, and reduce the accumulation of lipofuscin associated with aging. Furthermore, Vitamin K2 enhanced the stress resistance of C. elegans by maintaining mitochondrial morphology, alleviating mitochondrial stress, reducing ROS levels, and improving mitochondrial membrane potential and ATP production. Vitamin K2 activates the JNK-1/SIR-2.1/DAF-16 signaling pathway and upregulates the expression of downstream target genes such as ctl-1, ctl-2, sod-1, sod-3, and hsp-16.2. We conclude that appropriate doses of Vitamin K2 protect C. elegans from senescence by activating the JNK-1/SIR-2.1/DAF-16-mediated anti-mitochondrial oxidative stress pathway. These findings suggest that Vitamin K2 may have beneficial effects on lifespan and mitochondrial health in C. elegans, providing a basis for further investigation into its potential relevance for aging and age-related diseases in more complex model systems.
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Registered trials
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