Evidence map›Paper›PMID 42070096›Full record

ArticleChemical research in toxicology2026

Evaluating Dermal Bioactivity of Metal Additive Manufacturing Powders Using Human

Alexander Persson, Zuzanna Łyczyńska, Mariam Shahata, Oleksandr Kotlyar, Magnus Engwall, Eva Särndahl, Marcus Ehrström, Keira Melican, Inger Odnevall, Andi Alijagic

Abstract read
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In one paragraph

Article in Chemical research in toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alexander PerssonInflammatory Response and Infection Susceptibility Centre (iRiSC), Örebro University, SE-701 82 Örebro, Sweden.
Zuzanna ŁyczyńskaInflammatory Response and Infection Susceptibility Centre (iRiSC), Örebro University, SE-701 82 Örebro, Sweden.
Mariam ShahataDivision of Dermatology and Venereology, Department of Medicine Solna, Karolinska Institutet, Sweden and ME Gastro/HUD/Reuma, Karolinska University Hospital, SE-171 77 Stockholm, Sweden.
Oleksandr KotlyarMan-Technology-Environment Research Center (MTM), Örebro University, SE-701 82 Örebro, Sweden.
Magnus EngwallMan-Technology-Environment Research Center (MTM), Örebro University, SE-701 82 Örebro, Sweden.
Eva SärndahlInflammatory Response and Infection Susceptibility Centre (iRiSC), Örebro University, SE-701 82 Örebro, Sweden.
Marcus EhrströmNordiska Kliniken, SE-111-51 Stockholm, Sweden.
Keira MelicanDivision of Dermatology and Venereology, Department of Medicine Solna, Karolinska Institutet, Sweden and ME Gastro/HUD/Reuma, Karolinska University Hospital, SE-171 77 Stockholm, Sweden.
Inger OdnevallDepartment of Chemistry, Division of Surface and Corrosion Science, KTH Royal Institute of Technology, SE-100 44 Stockholm, Sweden.ORCID 0000-0003-2206-0082
Andi AlijagicInflammatory Response and Infection Susceptibility Centre (iRiSC), Örebro University, SE-701 82 Örebro, Sweden.ORCID 0000-0002-2403-7989

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metal additive manufacturing (AM) relies on alloy feedstock powders that may come into contact with the workers' skin during handling, yet skin-relevant data on metal release and biological reactivity remain limited. Here, we assessed the cutaneous bioactivity of the fine particle fraction of four gas-atomized Fe-based AM powders (316L stainless steel, Fe-powder A, and tooling steels B and C). Powders were sieved to <10 μm and characterized by scanning electron microscopy and X-ray photoelectron spectroscopy before and after incubation in artificial sweat (ASW). Metal biodissolution was quantified in ASW and keratinocyte culture medium using atomic absorption spectrophotometry. Cellular responses were evaluated in HaCaT keratinocytes using Cell Painting-based phenomics and multiplex cytokine/chemokine profiling and in an

Indexed as

SkinCell LineCytokinesHumansKeratinocytesPowdersCytokinesPowders

Identifiers

PMID42070096
PMCPMC13188164

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.