Evidence map›Paper›PMID 42070020›Full record

ArticleBMC immunology2026

Prognostic significance of inflammatory cytokine polymorphisms in AML: a study of IFNG, TNFA, and IL1B polymorphisms.

Tsatsralgerel Munkh-Erdene, Takayuki Saitoh, Miri Kitamura, Asumi Kojima, Takafumi Okawa, Tsukasa Oda, Eiji Miyauchi, Nobuo Sasaki, Ikuko Matsumura, Akira Matsumoto and 6 more

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In one paragraph

Article in BMC immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Tsatsralgerel Munkh-ErdeneDepartment of Laboratory Science, Graduate School of Health Sciences, Gunma University, Maebashi, Gunma, 371-8514, Japan.
Takayuki SaitohDepartment of Laboratory Science, Graduate School of Health Sciences, Gunma University, Maebashi, Gunma, 371-8514, Japan.
Miri KitamuraDepartment of Laboratory Science, Graduate School of Health Sciences, Gunma University, Maebashi, Gunma, 371-8514, Japan.
Asumi KojimaDepartment of Laboratory Science, Graduate School of Health Sciences, Gunma University, Maebashi, Gunma, 371-8514, Japan.
Takafumi OkawaDepartment of Laboratory Science, Graduate School of Health Sciences, Gunma University, Maebashi, Gunma, 371-8514, Japan.
Tsukasa OdaLaboratory of Mucosal Ecosystem Design, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan.
Eiji MiyauchiLaboratory of Mucosal Ecosystem Design, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan.
Nobuo SasakiLaboratory of Mucosal Ecosystem Design, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan.
Ikuko MatsumuraDepartment of Hematology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, Japan.
Akira MatsumotoDepartment of Hematology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, Japan.
Hisashi TakeiDepartment of Hematology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, Japan.
Nobuhiko KobayashiDepartment of Hematology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, Japan.
Yuri MiyazawaDepartment of Hematology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, Japan.
Yoshiyuki OgawaDivision of Blood Transfusion Service, Gunma University Hospital, Maebashi, Gunma, Japan.
Hiroshi HandaDepartment of Hematology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, Japan.
Nanami GotohDepartment of Laboratory Science, Graduate School of Health Sciences, Gunma University, Maebashi, Gunma, 371-8514, Japan. nanamig@gunma-u.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInflammatory cytokines influence the pathogenesis and progression of acute myeloid leukaemia (AML), not only by shaping the leukemic microenvironment, but also by supporting leukaemia stem cell survival and resistance to therapy. We, therefore, investigated the associations between the cytokine polymorphisms IFNG+874 A/T, TNFA-857 C/T, and IL1B -31 C/T and AML outcomes, as well as their influence on clinical features.

resultsNinety-three patients with AML and 117 healthy controls were analysed. The T allele of TNFA - 857 C/T (i.e., the high-expression allele) was observed at a significantly higher frequency in the patients with AML vs. the controls (AML vs. control = 24.7% vs. 16.2%, p = 0.04). Patients with the high-expression TT genotype had shorter overall survival (TT vs. CC = 46.0 vs. 224.1 months, p < 0.001). Patients with the high-expression non-CC genotype relapsed more frequently than those with the low-expression CC genotype (relapse vs. non-relapse = 55.8% vs. 26.9%, p = 0.01). No significant associations were observed for the IFNG + 874 A/T and IL1B -31 C/T polymorphism.

conclusionTNFA - 857 C/T polymorphisms can influence patient susceptibility to AML, as well as its prognosis. This suggests a link between chronic inflammation and leukemogenesis, as well as the potential value of TNFA genotyping in risk assessments.

Indexed as

Interferon-gammaInterleukin-1betaLeukemia, Myeloid, AcuteTumor Necrosis Factor-alphaAdultAgedAllelesFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHumansMaleMiddle AgedPolymorphism, GeneticPolymorphism, Single NucleotideInterferon-gammaInterleukin-1betaTumor Necrosis Factor-alphaAcute myeloid leukaemiaInflammatory cytokinesPolymorphisms

Identifiers

PMID42070020
PMCPMC13361117

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.