Evidence map›Paper›PMID 42069991›Full record

ArticleAnnals of surgical oncology2026

Do Postoperative Complications Impact Adjuvant Chemotherapy in Patients Undergoing Left-Side Pancreatectomy for Pancreatic Cancer?

Dillon C Cheung, Stephanie Yu, Chee-Chee Stucky, Lena Egbert, J Asher Jenkins, Chi-Fu Jeffrey Yang, Alexandra L Potter, George C Linderman, Richard J Bold, Nabil Wasif and 3 more

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Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Dillon C CheungDivision of Surgical Oncology and Endocrine Surgery, Department of Surgery, Mayo Clinic Arizona, Phoenix, AZ, USA.
Stephanie YuDivision of Surgical Oncology and Endocrine Surgery, Department of Surgery, Mayo Clinic Arizona, Phoenix, AZ, USA.
Chee-Chee StuckyDivision of Surgical Oncology and Endocrine Surgery, Department of Surgery, Mayo Clinic Arizona, Phoenix, AZ, USA.
Lena EgbertDivision of Surgical Oncology and Endocrine Surgery, Department of Surgery, Mayo Clinic Arizona, Phoenix, AZ, USA.
J Asher JenkinsDivision of Surgical Oncology and Endocrine Surgery, Department of Surgery, Mayo Clinic Arizona, Phoenix, AZ, USA.
Chi-Fu Jeffrey YangDepartment of Surgery, Massachusetts General Hospital, Boston, MA, USA.
Alexandra L PotterDepartment of Surgery, Massachusetts General Hospital, Boston, MA, USA.
George C LindermanDepartment of Surgery, Massachusetts General Hospital, Boston, MA, USA.
Richard J BoldDivision of Surgical Oncology and Endocrine Surgery, Department of Surgery, Mayo Clinic Arizona, Phoenix, AZ, USA.
Nabil WasifDivision of Surgical Oncology and Endocrine Surgery, Department of Surgery, Mayo Clinic Arizona, Phoenix, AZ, USA.
Yu-Hui ChangDepartment of Quantitative Health Sciences, Mayo Clinic Arizona, Scottsdale, AZ, USA.
Elizabeth B HabermannRobert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, USA.
Zhi Ven FongDivision of Surgical Oncology and Endocrine Surgery, Department of Surgery, Mayo Clinic Arizona, Phoenix, AZ, USA. Fong.Zhi@mayo.edu.ORCID http://orcid.org/0000-0001-6398-413X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundComplications after pancreatoduodenectomy for pancreatic ductal adenocarcinoma (PDAC) are associated with delays or omission of adjuvant chemotherapy (AC). Similar data for patients who undergo distal pancreatectomy (DP) are lacking.

methodsA retrospective cohort study was conducted using the SEER-Medicare database to identify patients who underwent upfront DP for PDAC (2010-2019). Multilevel logistic regression and Cox proportional hazards models were used to evaluate the association of postoperative complications with AC omission and delay as well as survival endpoints based on receipt of AC.

resultsOf 1029 patients identified, 613 (59.6 %) received AC. Patients with complications had lower rates of AC (50.0 % vs 61.1 %; p = 0.013) and multi-agent AC (25.0 % vs 28.2 %; p = 0.039) and higher rates of delays in AC (42.9 % vs 21.4 %; p < 0.001) than those without complications. In multivariable analysis, complications were associated with a lower rate of AC (hazard ratio [HR], 0.67; 95 % confidence interval [CI], 0.54-0.84; p < 0.001) and a higher rate of delayed AC (odds ratio [OR], 3.36; 95 % CI 1.92-5.91; p < 0.001). For survival, receipt of AC overall (HR, 0.56; 95 % CI 0.47-0.67; p < 0.001), even when delayed (HR, 0.72; 95 % CI 0.57-0.90; p = 0.005), was associated with better overall survival (OS) than no AC. However, delayed AC was associated with worse OS than timely AC (HR, 1.27; 95 % CI 1.01-1.62; p = 0.04).

conclusionsPatients who experienced a postoperative complication after DP for left-side PDAC had lower rates of AC overall and higher rates of delayed AC, both associated with worse OS.

Indexed as

Carcinoma, Pancreatic DuctalPancreatectomyPancreatic NeoplasmsPostoperative ComplicationsAgedAged, 80 and overChemotherapy, AdjuvantFemaleFollow-Up StudiesHumansMalePrognosisRetrospective StudiesSEER ProgramSurvival RateAdjuvant chemotherapyComplicationsDistal pancreatectomyLeft pancreatectomyPancreatic adenocarcinomaSEER-Medicare

Identifiers

PMID42069991

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.