Evidence map›Paper›PMID 42069947›Full record

ArticleEMBO reports2026

Plasmodesmal closure elicits stress responses.

Estee E Tee, Andrew Breakspear, Diana Papp, Hannah R Thomas, Catherine Walker, Annalisa Bellandi, Christine Faulkner

Abstract read
In one paragraph

Article in EMBO reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Estee E Tee *Cell and Developmental Biology, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, UK.ORCID 0000-0003-2613-5977
Andrew Breakspear *Cell and Developmental Biology, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, UK.ORCID 0000-0002-1863-3012
Diana Papp *Cell and Developmental Biology, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, UK.ORCID 0000-0002-2732-7543
Hannah R ThomasCell and Developmental Biology, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, UK.ORCID 0000-0001-5538-2331
Catherine WalkerCell and Developmental Biology, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, UK.ORCID 0000-0002-7222-6709
Annalisa BellandiCell and Developmental Biology, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, UK.ORCID 0000-0003-2615-5740
Christine FaulknerCell and Developmental Biology, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, UK. christine.faulkner@jic.ac.uk.ORCID 0000-0003-3905-8077

Funding

EC | H2020 | PRIORITY 'Excellent science' | H2020 European Research Council (ERC) 725459UKRI | Biotechnology and Biological Sciences Research Council (AFRC) BBS/E/J/000PR9796UKRI | Biotechnology and Biological Sciences Research Council (AFRC) BB/X007685/1UKRI | Biotechnology and Biological Sciences Research Council (AFRC) BB/X016056/1UKRI | Biotechnology and Biological Sciences Research Council (AFRC) BB/Y008782/1UKRI | Biotechnology and Biological Sciences Research Council (AFRC) NRP Doctoral Training ProgrammeUKRI | Engineering and Physical Sciences Research Council (SRC) EP/Z534390/1
6 · The paper itself

Abstract

Plant cells are connected to their neighbors via plasmodesmata facilitating the exchange of nutrients and signaling molecules. During immune responses, plasmodesmata close, but how this contributes towards a full immune response is unknown. To investigate this, we develop two transgenic lines which allow to induce plasmodesmal closure independently of immune elicitors, using the over-active CALLOSE SYNTHASE3 allele icals3m and the C-terminus of PDLP1 to drive callose deposition at plasmodesmata. Induction of plasmodesmal closure increases the expression of stress responsive genes, salicylic acid accumulation and resistance to Pseudomonas syringae DC3000. More homogeneous plasmodesmal closure using icals3m also leads to the accumulation of starch and sugars, decreases leaf growth, as well as hypersusceptibility to Botrytis cinerea. Based on the profile of responses, we conclude that plasmodesmal closure activates stress signaling, raising questions about the signals mediating this response and whether these responses occur in all circumstances when plasmodesmata close.

Indexed as

ArabidopsisPlasmodesmataStress, PhysiologicalArabidopsis ProteinsBotrytisDisease ResistanceGene Expression Regulation, PlantGlucansGlucosyltransferasesPlant DiseasesPlant LeavesPlants, Genetically ModifiedPseudomonas syringaeSalicylic AcidSignal Transduction1,3-beta-glucan synthaseArabidopsis ProteinscalloseGlucansGlucosyltransferasesSalicylic Acid

Identifiers

PMID42069947
PMCPMC13303860

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.