Evidence map›Paper›PMID 42069911›Full record

Trial reportScientific reports2026

Measuring and increasing the brain health span across adulthood: a public health imperative.

Lori G Cook, Jeffrey S Spence, Zhengsi Chang, Erin E Venza, Aaron Tate, Ian H Robertson, Mark D'Esposito, Geoffrey S F Ling, Jane G Wigginton, Sandra Bond Chapman

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04869111 (The BrainHealth Project, a Longitudinal Study in Generally Healthy Adults), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04869111 narecruitingnot on this map

The BrainHealth Project, a Longitudinal Study in Generally Healthy Adults

TypeinterventionalSponsorThe University of Texas at DallasRan2020 to 2038Enrolled100,000ConditionsHealthyArmsBrainHealth App-Based Program
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lori G CookCenter for BrainHealth ®, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Dallas, TX, USA. Lori.Cook@utdallas.edu.
Jeffrey S SpenceCenter for BrainHealth ®, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Dallas, TX, USA.
Zhengsi ChangCenter for BrainHealth ®, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Dallas, TX, USA.
Erin E VenzaCenter for BrainHealth ®, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Dallas, TX, USA.
Aaron TateCenter for BrainHealth ®, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Dallas, TX, USA.
Ian H RobertsonCenter for BrainHealth ®, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Dallas, TX, USA.
Mark D'EspositoDepartment of Molecular and Cell Biology, Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA.
Geoffrey S F LingDepartment of Neurology and Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Jane G WiggintonCenter for BrainHealth ®, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Dallas, TX, USA.
Sandra Bond ChapmanCenter for BrainHealth ®, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Dallas, TX, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extending brain health span - maintaining or improving cognitive, social, and emotional well-being - is critical to aligning health span with lifespan. This study examines 3-year outcomes from 3,966 adults (ages 19-94) in the BrainHealth Project, an online initiative integrating the BrainHealth Index (BHI) with cognitive training, lifestyle modules, and coaching. The BHI, assessed biannually, provides a multidimensional measure across factors of Clarity (cognitive function), Connectedness (social and purpose-driven engagement), and Emotional Balance (mental well-being). Results demonstrate sustained improvements in overall BHI and component factors, independent of baseline scores. Higher engagement with training tools - strategy-based learning, coaching, and brain-healthy habits - was associated with the greatest gains, underscoring the role of self-agency in brain health optimization. Improvements were observed across demographic groups, suggesting benefits regardless of age, gender, or education level. Findings support the potential for scalable, technology-driven interventions to help reduce years of cognitive decline while maximizing brain performance across the lifespan. Future efforts should focus on improving demographic diversity and retention as well as integrating precision brain health into public health initiatives.Trial registration: ClinicalTrials.gov, NCT04869111 (registered April 27, 2021).

Indexed as

BrainPublic HealthAdultAgedAged, 80 and overCognitionCognitive TrainingFemaleHumansMaleMiddle AgedAssessmentBrain healthCognitive trainingExecutive functionHealth promotionLongitudinal study

Identifiers

PMID42069911
PMCPMC13328555

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.