ArticleEJNMMI physics2026
Uncertainty analysis of single-time-point organ dosimetry compared with the multi-time-point method in radioimmunotherapy.
Article in EJNMMI physics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundA position paper released by the European Association of Nuclear Medicine emphasised the need for multidisciplinary engagement to establish dosimetry-based personalised treatment in Radionuclide therapy (RNT). The uncertainty analysis results often ignored in routine clinical practice should be incorporated into the dose calculations to improve the efficacy and accuracy of treatment. In this study, patients with haematological malignancies undergoing radioimmunotherapy were evaluated. Our study aimed to calculate the uncertainties associated with each parameter of the single time point (STP) dosimetry chain and compare the with multiple time points (MTP) in the bone marrow and liver results.
methods28 patients received an intravenous injection of
resultsThe mean absorbed dose per unit administered activity (DpA) to BM was 5.8 ± 1.7 mGy/MBq with MTP and 5.8 ± 1.6 mGy/MBq with STP, and to the liver was 2.9 ± 1.9 mGy/MBq with MTP and 3.1 ± 2.4 mGy/MBq with STP. The mean fractional uncertainty associated with total absorbed dose to BM was 13.18 ± 3.46% with MTP and 18.75 ± 3.22% with STP, and to liver was 5.77 ± 3.13% with MTP and 49.78 ± 25.36% with STP. A moderate positive relationship (R
conclusionThe absorbed dose uncertainty in STP was significantly higher compared to the MTP. Incorporating the uncertainty analysis for STP dosimetry parameters in routine clinical practice is strongly recommended. The accuracy in the acquisition time, population-based half-life and fitting function for time activity curve is vital for minimising uncertainty in STP dosimetry, which is less time-consuming and easier to implement in clinical practice than MTP.
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