Evidence map›Paper›PMID 42069828›Full record

ArticleApplied microbiology and biotechnology2026

Evolutionary engineering of Geobacillus thermoleovorans for growth on adipic acid and 1,4-butanediol.

Leonie Op de Hipt, Amelie Jäger, Tom Luthe, Volkan Julio Cevik, Angela Kranz, Benedikt Wynands, Julia Frunzke, Björn Usadel, Nick Wierckx

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Applied microbiology and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Leonie Op de HiptInstitute of Bio- and Geosciences IBG-1: Biotechnology and Bioeconomy Science Center (BioSC), Forschungszentrum Jülich, Jülich, Germany.
Amelie JägerInstitute of Bio- and Geosciences IBG-1: Biotechnology and Bioeconomy Science Center (BioSC), Forschungszentrum Jülich, Jülich, Germany.
Tom LutheInstitute of Bio- and Geosciences IBG-1: Biotechnology and Bioeconomy Science Center (BioSC), Forschungszentrum Jülich, Jülich, Germany.
Volkan Julio CevikInstitute of Bio- and Geosciences IBG-4: Bioinformatics, CEPLAS, and Bioeconomy Science Center (BioSC), Forschungszentrum Jülich, Jülich, Germany.
Angela KranzInstitute of Bio- and Geosciences IBG-4: Bioinformatics, CEPLAS, and Bioeconomy Science Center (BioSC), Forschungszentrum Jülich, Jülich, Germany.
Benedikt WynandsInstitute of Bio- and Geosciences IBG-1: Biotechnology and Bioeconomy Science Center (BioSC), Forschungszentrum Jülich, Jülich, Germany.
Julia FrunzkeInstitute of Bio- and Geosciences IBG-1: Biotechnology and Bioeconomy Science Center (BioSC), Forschungszentrum Jülich, Jülich, Germany.
Björn UsadelInstitute of Bio- and Geosciences IBG-4: Bioinformatics, CEPLAS, and Bioeconomy Science Center (BioSC), Forschungszentrum Jülich, Jülich, Germany.
Nick WierckxInstitute of Bio- and Geosciences IBG-1: Biotechnology and Bioeconomy Science Center (BioSC), Forschungszentrum Jülich, Jülich, Germany. n.wierckx@fz-juelich.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The plastic pollution crisis urges innovative recycling solutions. Promising approaches especially for polyester-containing wastes include enzymatic hydrolysis and microbial upcycling. For efficient enzymatic hydrolysis of polyesters, elevated temperatures (70-80 °C) are required, necessitating thermophilic microbial chassis for consolidated bioprocessing (CBP). In this study, we engineered Geobacillus thermoleovorans through adaptive laboratory evolution (ALE) for robust growth on adipic acid (AA) and 1,4-butanediol (BDO), two relevant monomers for example derived from poly(butylene adipate-co-terephthalate) (PBAT), enabling growth rates of up to 0.10 h

Indexed as

AdipatesButylene GlycolsDirected Molecular EvolutionGeobacillusMetabolic EngineeringPolyesters1,4-butanediolAdipatesadipic acidButylene GlycolsPolyestersAdaptive laboratory evolutionBiodegradable materialsCircular economyConsolidated bioprocessingMetabolic engineeringPBATPlastic upcyclingThermophilic bacteriaTranscriptomics

Identifiers

PMID42069828
PMCPMC13135583

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.