ArticleScientific data2026
Single-nucleus chromatin landscapes of cholestatic injury and repair in mice liver.
Article in Scientific data, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Single-nucleus chromatin landscapes of cholestatic injury and repair in mice liver.Scientific data · 2026Article
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8 authors.
Funding
Abstract
Liver progenitor-like cells (LPLCs) are essential for liver regeneration during some injury process, yet their epigenetic characters remain poorly understood. Using single-nucleus assay for transposase-accessible chromatin sequencing (snATAC-seq), we profiled chromatin accessibility in a mouse model of 3,5-diethoxycarbonyl-1,4-dihydrocollidin (DDC) diet-induced cholestasis at six time points: homeostasis (D0), injury (D8, D17), and repair (R2, R7, R21). We analyzed 75,452 high-quality nuclei, identifying 15 liver cell types, including LPLCs. Among 221,845 accessible chromatin regions, 192,079 showed differential accessibility. LPLCs exhibited enriched binding motifs for SWI/SNF (SMARCC1) and AP-1 (FOS, JUND and JUNB) complexes, highlighting their roles in transcriptional regulation. This study provides a comprehensive chromatin accessibility landscape of liver injury and regeneration, suggesting SWI/SNF and AP-1 as potential therapeutic targets.
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