ArticleNature communications2026
Synergistic Fe/Ni catalysis for electrochemical 1,1-difunctionalization of alkenes.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Alkene 1,1-difunctionalization holds significant importance in organic synthesis due to its ability to effectively enhance the complexity and functionality of molecular frameworks. Herein, we report an electrochemical strategy for 1,1-difunctionalization of halogenated aromatics with unactivated alkenes using synergistic Fe/Ni catalysis. This system integrates redox activity of nickel with Lewis acid functionality of iron: the nickel catalyst governs aryl halide oxidative addition and alkene migration, while iron species activates catalytic sites, stabilizes radical acceptors, and precisely regulates electrochemical reduction sequences/selectivities. The reaction system is applicable to a wide range of substrates, including electron-rich and electron-deficient aryl halides, polycyclic compounds, and bioactive natural products (100 examples). Gram-scale synthesis maintains 63% yield, supporting industrial viability. Mechanistic studies elucidate the unique cooperativity of this iron-nickel bimetallic system, providing a theoretical framework for the design of diverse difunctionalization reactions.
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