ArticleNPJ systems biology and applications2026
Design principles for robust multistability in coupled feedforward-feedback regulatory circuits.
Article in NPJ systems biology and applications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Feedforward loops (FFLs) and feedback loops (FBLs) are ubiquitous network motifs that mediate signal filtering, pulse generation, and state switching; yet, how coupling FBLs to FFLs produces robust multistability-a key mechanism for cellular decision-making-remains unclear. Here, we systematically investigate coupled FFL-FBL architectures by focusing on two prevalent FFL types, each with AND or OR logic, yielding four distinct frameworks. For each framework, we enumerate all 3
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