Evidence map›Paper›PMID 42069750›Full record

ArticleScientific reports2026

Intense pulsed light rejuvenates UVB-induced photoaging in human keratinocytes and guinea pig skin by inhibition of ERK-AP-1-MMP pathway.

Congcong Liu, Wenzhi Hu, Xiaoyang Zhang, Mingmin Lu, Jiayi Xiang, Lina Tan, Ye Tao, Kui Ma, Lixia Zhang, Zhaoting Yang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Congcong Liu *Department of Dermatology, Air Force Medical Center, Air Force Medical University, Beijing, 100142, China.
Wenzhi Hu *Department of Dermatology, Air Force Medical Center, Air Force Medical University, Beijing, 100142, China.
Xiaoyang Zhang *Graduate School of Hebei North University, Zhangjiakou, 075000, Hebei, China.
Mingmin LuDepartment of Dermatology, Air Force Medical Center, Air Force Medical University, Beijing, 100142, China.
Jiayi XiangGraduate School of China Medical University, Shenyang, 110000, Liaoning, China.
Lina TanDepartment of Dermatology, Air Force Medical Center, Air Force Medical University, Beijing, 100142, China.
Ye TaoDepartment of Dermatology, Air Force Medical Center, Air Force Medical University, Beijing, 100142, China.
Kui MaDepartment of Plastic and Reconstructive Surgery, Senior Department of Burns and Plastic Surgery, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, 100048, China.
Lixia ZhangDepartment of Plastic and Reconstructive Surgery, Senior Department of Burns and Plastic Surgery, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, 100048, China.
Zhaoting YangLaboratory of Clinical Medicine, Air Force Medical Center, Air Force Medical University, Beijing, 100142, China. yangzt88@foxmail.com.
Weijie GuDepartment of Dermatology, Air Force Medical Center, Air Force Medical University, Beijing, 100142, China. guweijie113@163.com.

Funding

National Natural Science Foundation of China 82373460
6 · The paper itself

Abstract

Skin photoaging is predominantly induced by ultraviolet (UV) irradiation. Intense pulsed light (IPL) is a commonly employed non-ablative treatment for photoaging. However, the effects and mechanisms of IPL on UV-induced skin photoaging remain insufficiently understood. In this study, we aimed to examine the anti-photoaging effects of IPL and elucidate the underlying mechanisms. This study revealed that UV triggered extracellular signal-regulated kinases (ERK) together with c-jun NH2-terminal kinase (JNK), while selectively suppressed UV-induced ERK phosphorylation while activating JNK in human skin keratinocytes. The different ERK/JNK expression patterns induced by UV and IPL resulted in distinct c-fos/c-jun (activator protein 1) phosphorylation, cyclin D1 expression, and matrix metalloproteinase (MMP) secretion. In vivo, IPL inhibited MMP expression in guinea pig skin and promoted c-fos/c-jun phosphorylation, epidermal proliferation, and collagen remodeling. These findings indicated that ERK was involved in IPL rejuvenation by regulating c-fos, c-jun, cyclin D1, and MMPs, providing a potential target for skin rejuvenation.

Indexed as

Extracellular Signal-Regulated MAP KinasesKeratinocytesMatrix MetalloproteinasesSkinSkin AgingTranscription Factor AP-1Ultraviolet RaysAnimalsCyclin D1Guinea PigsHumansPhosphorylationProto-Oncogene Proteins c-fosSignal TransductionCyclin D1Extracellular Signal-Regulated MAP KinasesMatrix MetalloproteinasesProto-Oncogene Proteins c-fosTranscription Factor AP-1Extracellular signal-regulated kinasesIntense pulsed lightMatrix metalloproteinasePhotoagingUltraviolet

Identifiers

PMID42069750
PMCPMC13328571

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.