Evidence map›Paper›PMID 42069707›Full record

ArticleNature communications2026

Shock-scattering micro-histotripsy-aided fine needle aspiration for enhanced biomarker profiling and cytopathology.

Joy Wang, Pradyumna Kedarisetti, Ewan A McAlister, Matthew G Mallay, Jeffrey K Woodacre, Benjamin A Adam, Remegio J Maglantay, Juan Jovel, Frank R Wuest, Jeremy A Brown and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Joy WangDepartment of Biomedical Engineering, University of Alberta, Edmonton, AB, Canada. joy3@ualberta.ca.ORCID http://orcid.org/0009-0003-0065-8136
Pradyumna KedarisettiDepartment of Electrical and Computer Engineering, University of Alberta, Edmonton, AB, Canada.ORCID http://orcid.org/0000-0002-2522-5535
Ewan A McAlisterDepartment of Electrical and Computer Engineering, University of Alberta, Edmonton, AB, Canada.ORCID http://orcid.org/0009-0000-7466-8722
Matthew G MallaySoundBlade Medical Inc., Halifax, NS, Canada.
Jeffrey K WoodacreDaxsonics Inc., Halifax, NS, Canada.
Benjamin A AdamDepartment of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada.ORCID http://orcid.org/0000-0003-1908-1739
Remegio J MaglantayDepartment of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada.
Juan JovelFaculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.
Frank R WuestDepartment of Oncology, University of Alberta, Edmonton, AB, Canada.
Jeremy A BrownDepartment of Electrical and Computer Engineering, Dalhousie University, Halifax, NS, Canada.
Roger J ZempDepartment of Biomedical Engineering, University of Alberta, Edmonton, AB, Canada. rzemp@ualberta.ca.ORCID http://orcid.org/0000-0001-6802-5624

Funding

Alberta Cancer Foundation ACF JFMRP 27587Canadian Cancer Society Research Institute (Société Canadienne du Cancer) CCS 702032
6 · The paper itself

Abstract

Core needle biopsy is the gold standard procedure for sampling tissues for pathology-based diagnostics. However, it produces significant tissue damage and may lead to undue pain and risk of complications such as infections. Alternatives such as fine needle aspiration and liquid biopsy have not yet achieved the same widespread utility owing to the limited abundance of cells and relevant biomarkers in extracted samples. Here we introduce a shock-scattering micro-histotripsy-aided fine needle aspiration technology which uses cavitation to liquefy nano-liter to micro-liter volumes to produce tissue homogenates with both intact and lysed cells. It permits not only conventional cytopathology with high success but sufficient high-quality tissue homogenates to enable reliable ancillary testing such as genetic biomarker profiling and even whole genome sequencing with improved quality compared to formalin-fixed samples. Our approach represents an advance in tissue diagnostics with orders of magnitude less damage than core-needle biopsy procedures.

Indexed as

BiomarkersAnimalsBiopsy, Fine-NeedleHumansBiomarkers

Identifiers

PMID42069707
PMCPMC13341763

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.