Evidence map›Paper›PMID 42069698›Full record

ArticleNature communications2026

Multicohort analysis unveils axon guidance pathways linking small for gestational age to spirometric restriction.

James F Read, Debra A Stern, Tara F Carr, Amber L Spangenberg, Meiven Yang, Rosa I Luna-Ramirez, Stefano Guerra, Wayne J Morgan, Alex T Binder, Jeffrey J VanWormer and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

James F ReadAsthma and Airway Disease Research Center, University of Arizona, Tucson, AZ, USA. jread@arizona.edu.ORCID http://orcid.org/0000-0003-2962-6835
Debra A SternAsthma and Airway Disease Research Center, University of Arizona, Tucson, AZ, USA.
Tara F CarrAsthma and Airway Disease Research Center, University of Arizona, Tucson, AZ, USA.
Amber L SpangenbergAsthma and Airway Disease Research Center, University of Arizona, Tucson, AZ, USA.
Meiven YangDepartment of Immunobiology, The University of Arizona College of Medicine, Tucson, AZ, USA.ORCID http://orcid.org/0000-0002-0522-7111
Rosa I Luna-RamirezSchool of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, AZ, USA.
Stefano GuerraAsthma and Airway Disease Research Center, University of Arizona, Tucson, AZ, USA.
Wayne J MorganAsthma and Airway Disease Research Center, University of Arizona, Tucson, AZ, USA.
Alex T BinderOffice of Informatics and Information Technology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Jeffrey J VanWormerCenter for Clinical Epidemiology & Population Health, Marshfield Clinic Research Institute, Marshfield, WI, USA.
Christine M SeroogyDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Rachel L MillerDivision of Clinical Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-4214-3347
Edward M ZorattiDivision of Allergy and Clinical Immunology, Department of Internal Medicine, Henry Ford Health, Detroit, MI, USA.
Carole OberDepartment of Human Genetics, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-4626-9809
Daniel J JacksonDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Sean W LimesandSchool of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, AZ, USA.
Diane R GoldDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
James E GernDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.ORCID http://orcid.org/0000-0002-6667-4708
CADRE consortium
Anthony Bosco *Asthma and Airway Disease Research Center, University of Arizona, Tucson, AZ, USA.ORCID http://orcid.org/0000-0002-4335-615X
Fernando D Martinez *Asthma and Airway Disease Research Center, University of Arizona, Tucson, AZ, USA.

Funding

VITAMIN AP30CA023074 · NCI · UNIVERSITY OF ARIZONA · PI Dan Theodorescu · 1985 to 2026
$110.2M
Children's Allergy and Asthma Data Repository (CADRE) SupplementU24AI179612 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI James E. Gern · 2024 to 2026
$3.2M
NCI NIH HHS P30 CA023074U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) U24AI179612U.S. Department of Health & Human Services | NIH | NIH Office of the Director (OD) UG3/UH3OD023282U.S. Department of Health & Human Services | NIH | NIH Office of the Director (OD) UG3/UH3OD023290
6 · The paper itself

Abstract

Children born small for gestational age (SGA) face elevated risks of metabolic, cardiovascular, respiratory, and neurodevelopmental disorders, as well as premature mortality, yet the underlying mechanisms remain only partly understood. We analyze blood proteomic data from multiple birth cohorts to identify molecular pathways linked to SGA and to later-life lung function. We find that approximately one-third of SGA children exhibit a distinct molecular endotype marked by dysregulation of axon-guidance proteins in cord blood. In peripheral blood collected later in life, these proteins are inversely associated with contemporaneous spirometric restriction. Using GWAS data and an experimental sheep model, we obtain convergent evidence that axon-guidance genes are associated with spirometric indices (FEV

Indexed as

Axon GuidanceInfant, Small for Gestational AgeLungAnimalsDevelopmental Origins of Health and DiseaseFemaleGenome-Wide Association StudyHumansMalePregnancyProteomicsSheep

Identifiers

PMID42069698
PMCPMC13342533

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.