Evidence map›Paper›PMID 42069642›Full record

ArticleInfectious agents and cancer2026

Genomic and transcriptomic differences between neuroendocrine neoplasms and carcinomas with human papillomavirus (HPV).

Morgann Madill, Udhayvir Grewal, Harris Krause, Andrew Elliott, Marya Wahidi, Janet S Rader, Deanna Teoh, Soo J Park, John Wallbillich, David J Benjamin and 17 more

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Article in Infectious agents and cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

27 authors.

Morgann Madill *University of Minnesota, Minneapolis, MN, USA.
Udhayvir Grewal *Winship Cancer Institute of Emory University, Atlanta, GA, USA.
Harris KrauseCaris Life Sciences, Phoenix, AZ, USA.
Andrew ElliottCaris Life Sciences, Phoenix, AZ, USA.
Marya WahidiWayne State University, Detroit, MI, USA.
Janet S RaderMedical College of Wisconsin, Milwaukee, WI, USA.
Deanna TeohUniversity of Minnesota, Minneapolis, MN, USA.
Soo J ParkUniversity of California San Diego, La Jolla, CA, USA.
John WallbillichKarmanos Cancer Institute/Wayne State University, Detroit, MI, USA.
David J BenjaminHoag Family Cancer Institute, Newport Beach, CA, USA.
Arash Rezazadeh KalebastyUniversity of California Irvine, Irvine, CA, USA.
Penelope Duerksen-HughesLoma Linda University, Loma Linda, CA, USA.
Robert MorrisKarmanos Cancer Institute/Wayne State University, Detroit, MI, USA.
Radhika GogoiKarmanos Cancer Institute/Wayne State University, Detroit, MI, USA.
Fadi ZaiemCreighton University, Phoenix, AZ, USA.
Thomas J HerzogUniversity of Cincinnati College of Medicine, Cincinnati, OH, USA.
Premal H ThakerWashington University and Siteman Cancer Center in St. Louis, St. Louis, MO, USA.
Dave BryantCaris Life Sciences, Phoenix, AZ, USA.
Matthew OberleyCaris Life Sciences, Phoenix, AZ, USA.
Heloisa SoaresUniversity of Utah Huntsman Cancer Institute, Salt Lake City, UT, USA.
Joanne XiuCaris Life Sciences, Phoenix, AZ, USA.
Andrew HintonCaris Life Sciences, Phoenix, AZ, USA.
Deepti JainWayne State University, Detroit, MI, USA.
Britt K EricksonUniversity of Minnesota, Minneapolis, MN, USA.
Martina BazzaroUniversity of Minnesota, Minneapolis, MN, USA.
Emil LouUniversity of Minnesota, Minneapolis, MN, USA.
Rouba Ali FehmiUniversity of Michigan, Ann Arbor, MI, USA. alifehmi@med.umich.edu.ORCID https://orcid.org/0009-0003-0642-535X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHuman papillomavirus (HPV) is a well-established oncogenic virus implicated in the development of several epithelial cancers, most notably cervical, anogenital, and oropharyngeal carcinomas. In contrast, neuroendocrine neoplasms (NENs)-a heterogeneous group of malignancies arising from neuroendocrine cells across various organ systems-have not traditionally been linked to HPV infection. In this study, we performed extensive genomic and transcriptomic profiling to compare HPV-positive NENs to HPV-positive non-NENs across anatomical sites, aiming to uncover biologically and clinically actionable differences.

methodsHPV16- and HPV18-positive tumors were identified from 101,343 solid tumors profiled at Caris Life Sciences (Phoenix, AZ) with DNA and RNA sequencing. Prevalence of pathogenic mutations and copy number amplifications were calculated. Fisher's exact/χ

resultsHPV positivity was most frequent in cervical carcinomas (70%, 1200/1716). Importantly, 6% (96/1620) of NENs from all tissues were positive for HPV16 or HPV18. Among HPV-positive NENs, 93% were high-grade compared to 54% observed in HPV-negative NENs (p < 0.001), highlighting a strong association between HPV and tumor aggressiveness in this subset. Analysis of HPV-associated sites (cervix, anorectal region, and head and neck) revealed that HPV-positive NENs possess distinct genomic and transcriptomic landscapes compared to HPV-positive non-NENs. Notably, interferon signaling was significantly suppressed in HPV-positive NENs, suggesting a unique tumor-immune microenvironment.

conclusionsOur findings indicate that HPV-positive NENs form a distinct subset with unique genomic features, including reduced interferon signaling, compared to HPV-positive non-NENs. Thus, future studies focused on evaluating HPV status, along with genomic and transcriptomic characteristics, may uncover biologically and clinically actionable distinctions for this rare yet clinically significant tumor subgroup. CLINICAL TRIAL NUMBER: Not applicable.

Identifiers

PMID42069642
PMCPMC13270718

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