Evidence map›Paper›PMID 42069601›Full record

ArticleJournal of neuroinflammation2026

ALS-FTD-linked CCNF

Liam Robinson, Dzung Do-Ha, Flora Cheng, Claire H Stevens, Rossana Rosa Porto, Madilyn Coles, Jamesha Subachandran, Predrag Kalajdzic, Joanna Lui, Rachelle Balez and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Liam RobinsonSchool of Science and Molecular Horizons, University of Wollongong, Wollongong, NSW, Australia.
Dzung Do-HaSchool of Science and Molecular Horizons, University of Wollongong, Wollongong, NSW, Australia.
Flora ChengMotor Neuron Disease Research Centre, Macquarie Medical School, Faculty of Medicine Health and Human Sciences, Macquarie University, Sydney, Australia.
Claire H StevensSchool of Science and Molecular Horizons, University of Wollongong, Wollongong, NSW, Australia.
Rossana Rosa PortoSchool of Medicine, Western Sydney University, Campbelltown, NSW, 2560, Australia.
Madilyn ColesSchool of Medicine, Western Sydney University, Campbelltown, NSW, 2560, Australia.
Jamesha SubachandranSchool of Medicine, Western Sydney University, Campbelltown, NSW, 2560, Australia.
Predrag KalajdzicTranslational Vectorology Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, 2145, Australia.
Joanna LuiFaculty of Medicine and Health, School of Medical Sciences, Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia.
Rachelle BalezSchool of Science and Molecular Horizons, University of Wollongong, Wollongong, NSW, Australia.
Sonia Sanz MuñozSchool of Science and Molecular Horizons, University of Wollongong, Wollongong, NSW, Australia.
Mauricio Castro Cabral-da-SilvaSchool of Science and Molecular Horizons, University of Wollongong, Wollongong, NSW, Australia.
Tracey BergSchool of Science and Molecular Horizons, University of Wollongong, Wollongong, NSW, Australia.
Marco MorschMotor Neuron Disease Research Centre, Macquarie Medical School, Faculty of Medicine Health and Human Sciences, Macquarie University, Sydney, Australia.
Leszek LisowskiTranslational Vectorology Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, 2145, Australia.
Rachel H TanFaculty of Medicine and Health, School of Medical Sciences, Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia.
Gaétan BurgioDivision of Genome Sciences and Cancer, The Shine Dalgarno Centre for RNA Innovation, the John Curtin School of Medical Research, The Australian National University, Canberra, Australia.
Tim KarlSchool of Medicine, Western Sydney University, Campbelltown, NSW, 2560, Australia.
Albert LeeMotor Neuron Disease Research Centre, Macquarie Medical School, Faculty of Medicine Health and Human Sciences, Macquarie University, Sydney, Australia.
Roger S ChungMotor Neuron Disease Research Centre, Macquarie Medical School, Faculty of Medicine Health and Human Sciences, Macquarie University, Sydney, Australia.
Ian BlairMotor Neuron Disease Research Centre, Macquarie Medical School, Faculty of Medicine Health and Human Sciences, Macquarie University, Sydney, Australia.
Lezanne OoiSchool of Science and Molecular Horizons, University of Wollongong, Wollongong, NSW, Australia. lezanne@uow.edu.au.

Funding

Australian Research Council CE230100021National Health and Medical Research Council APP1107644National Health and Medical Research Council APP1135720
6 · The paper itself

Abstract

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative diseases with overlapping pathology. Mutations in CCNF, encoding the E3 ubiquitin ligase, Cyclin F, can cause ALS, FTD, or both, even within the same family. Most prior studies of CCNF

Indexed as

Amyotrophic Lateral SclerosisAstrocytesFrontotemporal DementiaHippocampusMitochondriaMotor NeuronsAnimalsCells, CulturedDisease Models, AnimalFemaleHumansMaleMiceMice, Inbred C57BLMice, TransgenicALS-FTDAstrocyte dysfunctionCCNF S621GCRISPR/Cas9 mouse modelHuman post-mortem tissueiPSCsMitochondrial dysfunctionNeurodegenerationNeuronal excitability

Identifiers

PMID42069601
PMCPMC13289496

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.