Evidence map›Paper›PMID 42069595›Full record

ArticleJournal of orthopaedic surgery and research2026

Intramedullary cement augmentation in locking plate fixation for Neer four-part proximal humeral fractures: a technique for preventing early mechanical failure.

Zhixiang Chen, Chengjun Hao, Bingjun Cui, Lang Wu, Chuangong Wang, Zhenqing Zhang, Shaoyu Han

Abstract read
In one paragraph

Article in Journal of orthopaedic surgery and research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhixiang ChenTrauma Center, Huai'an Hospital Affiliated to Yangzhou University (The Fifth People's Hospital of Huai'an City), Huai'an, 223001, Jiangsu Province, China.
Chengjun HaoTrauma Center, Huai'an Hospital Affiliated to Yangzhou University (The Fifth People's Hospital of Huai'an City), Huai'an, 223001, Jiangsu Province, China.
Bingjun CuiTrauma Center, Huai'an Hospital Affiliated to Yangzhou University (The Fifth People's Hospital of Huai'an City), Huai'an, 223001, Jiangsu Province, China.
Lang WuTrauma Center, Huai'an Hospital Affiliated to Yangzhou University (The Fifth People's Hospital of Huai'an City), Huai'an, 223001, Jiangsu Province, China.
Chuangong WangTrauma Center, Huai'an Hospital Affiliated to Yangzhou University (The Fifth People's Hospital of Huai'an City), Huai'an, 223001, Jiangsu Province, China.
Zhenqing ZhangTrauma Center, Huai'an Hospital Affiliated to Yangzhou University (The Fifth People's Hospital of Huai'an City), Huai'an, 223001, Jiangsu Province, China.
Shaoyu HanTrauma Center, Huai'an Hospital Affiliated to Yangzhou University (The Fifth People's Hospital of Huai'an City), Huai'an, 223001, Jiangsu Province, China. Hanshaoyu10094@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLocking plate fixation for Neer four-part proximal humeral fractures is frequently complicated by varus collapse and screw cut-out, leading to mechanical failure, particularly in osteoporotic bone. This study evaluates the clinical and radiographic outcomes of a modified technique involving intramedullary polymethylmethacrylate (PMMA) bone cement augmentation applied during its thread-forming phase to create an internal support structure.

methodsIn this retrospective cohort study, 66 consecutive patients with Neer four-part proximal humeral fractures treated between January 2023 and June 2024 were enrolled and divided into two groups: 31 patients underwent locking plate ORIF with intramedullary PMMA cement augmentation (augmentation group), and 35 patients received conventional locking plate fixation without cement (control group). Patient demographics, surgical details, and perioperative data were recorded. Primary outcomes were radiographic: fracture union time, and changes in the neck-shaft angle (NSA) and humeral head height (HHH). Secondary outcomes included the Constant-Murley Score (CMS), Visual Analog Scale (VAS) for pain, and all complications.

resultsThe two groups were well matched demographically (mean age 77.9 ± 3.6 years; P > 0.05). All fractures achieved union, with significantly faster healing in the augmentation group (14.42 ± 1.45 vs. 15.10 ± 1.12 weeks; P = 0.0245). Radiographic stability was markedly superior in the augmentation group: mean loss of NSA was 1.4° ± 1.2° versus 2.8° ± 1.9° (P = 0.001), and mean loss of HHH was 0.6 ± 0.5 mm versus 1.8 ± 1.1 mm (P < 0.001). Critically, no patient (0%) in the augmentation group experienced significant loss of reduction (defined as > 5° change in NSA or > 3 mm loss of HHH), compared to three patients (8.57%) in the control group (P = 0.095). Early postoperative pain was significantly reduced in the augmentation group on day 1 (VAS: 4.35 ± 1.27 vs. 5.20 ± 1.39; P = 0.0065) and day 3 (3.29 ± 0.45 vs. 3.63 ± 0.64; P = 0.0044). Functional recovery was significantly better at 1 month (CMS: 51.61 ± 6.16 vs. 48.54 ± 7.06; P = 0.0447) and 3 months (66.10 ± 10.32 vs. 62.09 ± 8.56; P = 0.0467). The complication rate was low; notably, radiographic avascular necrosis occurred in only one patient (3.23%) in the augmentation group versus five patients (14.29%) in the control group (P = 0.122). No cases of screw cut-out, implant failure, or reoperation were recorded.

conclusionIntramedullary augmentation with thread-forming phase PMMA cement is a highly effective adjunct to locking plate fixation for Neer four-part proximal humeral fractures. In this cohort, no patient in the augmentation group experienced significant loss of reduction, suggesting that the technique may reduce the risk of early mechanical failure, provide superior radiographic stability, reduce early postoperative pain, accelerate early functional recovery, and demonstrate a clinically meaningful trend toward lower AVN incidence. It represents a reliable joint-preserving option for managing these complex fractures, particularly in patients where maintaining the native glenohumeral joint is a priority.

Indexed as

Bone CementsBone PlatesFracture Fixation, InternalFracture Fixation, IntramedullaryPolymethyl MethacrylateShoulder FracturesAgedAged, 80 and overCohort StudiesFemaleHumansMaleRetrospective StudiesTreatment OutcomeBone CementsPolymethyl MethacrylateBone cementFour-part fractureLocking plateMechanical failureProximal humeral fracture

Identifiers

PMID42069595
PMCPMC13520394

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.