Evidence map›Paper›PMID 42069549›Full record

ArticleBMC pediatrics2026

Osteoporosis in children and adolescents with transfusion-dependent thalassemia and the diagnostic value of different indicators.

Xinxia Li, Liuhua Liao, Li Wang, Yang Zhang, Baifeng Huang, Rufen Chen, Chushan Wu, Xiuling Huang, Qianwen Guan, Guohua Chen and 1 more

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Article in BMC pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Xinxia Li *Department of Endocrinology, Affiliated Shenzhen Children's Hospital of Shantou University Medical College, 7019 Yitian Road, Futian District, Shenzhen, Guangdong, 518038, China.
Liuhua Liao *Department of Pediatrics, Huizhou Central People's Hospital, Huizhou, Guangdong, 516001, China.
Li WangDepartment of Endocrinology, Affiliated Shenzhen Children's Hospital of Shantou University Medical College, 7019 Yitian Road, Futian District, Shenzhen, Guangdong, 518038, China.
Yang ZhangDepartment of Pediatrics, Huizhou First Hospital, Huizhou, Guangdong, 516001, China.
Baifeng HuangDepartment of Radiology, Huizhou Central People's Hospital, Huizhou, Guangdong, 516001, China.
Rufen ChenDepartment of Nuclear Medicine, Huizhou Central People's Hospital, Huizhou, Guangdong, 516001, China.
Chushan WuDepartment of Endocrinology, Affiliated Shenzhen Children's Hospital of Shantou University Medical College, 7019 Yitian Road, Futian District, Shenzhen, Guangdong, 518038, China.
Xiuling HuangDepartment of Pediatrics, Huizhou Central People's Hospital, Huizhou, Guangdong, 516001, China.
Qianwen GuanDepartment of Radiology, Huizhou Central People's Hospital, Huizhou, Guangdong, 516001, China.
Guohua ChenDepartment of Pediatrics, Huizhou First Hospital, Huizhou, Guangdong, 516001, China.
Zhe SuDepartment of Endocrinology, Affiliated Shenzhen Children's Hospital of Shantou University Medical College, 7019 Yitian Road, Futian District, Shenzhen, Guangdong, 518038, China. su_zhe@126.com.

Funding

China Children's Growth and Development Academic Exchange Special Fund, Pediatric Endocrinology Young and Middle-aged Physicians Growth Research Fund Z-2019-41-2201Medical Science and Technology Research Foundation of Guangdong Province, China A2022443Sanming Project of Medicine in Shenzhen SZSM202411011Science and Technology Planning Project of Huizhou, China 2019C0603010Science and Technology Planning Project of Huizhou, China 2022CZ010007Science and Technology Planning Project of Huizhou, China 2023CZ010042Science and Technology Planning Project of Huizhou, China 2023CZ010074Shenzhen Fundamental Research Program KCXFZ20201221173400002Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialties SZGSP012
6 · The paper itself

Abstract

backgroundThe study aimed to investigate the prevalence of osteoporosis in children and adolescents with transfusion-dependent thalassemia (TDT) and evaluate the diagnostic value of different osteoporosis indicators.

methodsClinical data were collected from children and adolescents with TDT treated with blood transfusion between March 2022 and January 2024 at Huizhou Central People's Hospital and Huizhou First Hospital. The patients were grouped according to the presence of osteoporosis (International Society for Clinical Densitometry [ISCD] criteria).

resultsOf 138 patients included in the study, 48 (34.8%) had osteoporosis. The patients with osteoporosis mainly had asymptomatic grade I fractures of the spine. Using the dual-X-ray absorptiometry (DXA) standards from the World Health Organization, height-corrected TBLH Z-score ≤-2 was associated with osteoporosis (30.4% vs. 14.9%, P = 0.035), displaying 30.4% sensitivity and 85.1% specificity. According to the Chinese DXA standards, height-corrected and age-specific Z-scores ≤-2 were not associated with osteoporosis.

conclusionThe prevalence of osteoporosis among children and adolescents with TDT was 34.8%, indicating the need for screening for osteoporosis in that population. In TDT, the diagnosis of osteoporosis requires early detection of spinal fractures because bone density assessed by DXA is of limited value.

Indexed as

OsteoporosisThalassemiaAbsorptiometry, PhotonAdolescentBlood TransfusionBone DensityChildChinaFemaleHumansMalePrevalenceSensitivity and SpecificityAdolescentsBone mineral densityChildrenOsteoporosisTransfusion-dependent thalassemia

Identifiers

PMID42069549
PMCPMC13281646

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.