Evidence map›Paper›PMID 42069447›Full record

ArticleTrends in biochemical sciences2026

Thermospermine drives dual-action ribosomes to shape plant xylem development.

Hsin-Yen Larry Wu, Polly Yingshan Hsu

Abstract read
In one paragraph

Article in Trends in biochemical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Hsin-Yen Larry WuDepartment of Biochemistry & Molecular Biology, Michigan State University, East Lansing, MI 48824, USA.
Polly Yingshan HsuDepartment of Biochemistry & Molecular Biology, Michigan State University, East Lansing, MI 48824, USA. Electronic address: pollyhsu@msu.edu.

Funding

Regulation of upstream open reading frames in mRNA stability and translationR35GM155375 · NIGMS · MICHIGAN STATE UNIVERSITY · PI Polly Hsu · 2024 to 2026
$1.1M
NIGMS NIH HHS R35 GM155375
6 · The paper itself

Abstract

The formation of xylem vessels depends on a balance between transcription factors SACLs and LHW, whose translation is controlled by thermospermine. A recent study shows that a conserved rRNA methylation by OVERACHIEVER enables thermospermine binding, allowing ribosomes to oppositely regulate SACL and LHW translation to direct plant xylem cell fate.

Indexed as

RibosomesSpermineXylemSperminethermosperminecell-fate decisionpolyaminerRNA methylationtranslational controlxylem development

Identifiers

PMID42069447
PMCPMC13229610

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.