Evidence map›Paper›PMID 42068860›Full record

ArticleSocial science & medicine (1982)2026

Aging-related deficits accumulation and cancer-related outcomes in testicular and prostate cancer: Cross-sectional and longitudinal findings.

Michael A Hoyt, Karen Llave, Judith E Carroll, Marcie D Haydon

Abstract read
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In one paragraph

Article in Social science & medicine (1982), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

4 authors.

Michael A HoytDepartment of Population Health and Disease Prevention, Joe C. Wen School of Population & Public Health, University of California, Irvine, 856 Health Sciences Road, Suite 3800, Irvine, CA, 92617-9937, USA; Chao Family Comprehensive Cancer Center, University of California, Irvine, 200 S Manchester Road, Orange, CA, 92868, USA; Center for Biomarker & Biobehavioral Research, University of California, Irvine, 856 Health Sciences Road, Irvine, CA, 92617-9937, USA. Electronic address: mahoyt@uci.edu.
Karen LlaveDepartment of Population Health and Disease Prevention, Joe C. Wen School of Population & Public Health, University of California, Irvine, 856 Health Sciences Road, Suite 3800, Irvine, CA, 92617-9937, USA; Chao Family Comprehensive Cancer Center, University of California, Irvine, 200 S Manchester Road, Orange, CA, 92868, USA.
Judith E CarrollDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, 760 Westwood Plaza, Los Angeles, CA, 90095, USA.
Marcie D HaydonDepartment of Population Health and Disease Prevention, Joe C. Wen School of Population & Public Health, University of California, Irvine, 856 Health Sciences Road, Suite 3800, Irvine, CA, 92617-9937, USA.

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Christine Hui · 1994 to 2026
$57.9M
A Biobehavioral Intervention to Reduce Adverse Outcomes in Young Adult Testicular Cancer SurvivorsR01CA276143 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Michael A Hoyt · 2023 to 2026
$2.7M
NCI NIH HHS P30 CA062203NCI NIH HHS R01 CA276143
6 · The paper itself

Abstract

This study examined how aging-related deficit burden relates to cancer-specific outcomes in men diagnosed at markedly different developmental periods and with different cancer experiences. A modified Deficit Accumulation Index (DAI), a multi-system measure of aging based on proportional health deficits, was computed in two cohorts. Study 1 used cross-sectional data from 171 young adult testicular cancer survivors (ages 18-29). Study 2 used longitudinal data from 114 men with localized prostate cancer (ages 51-81) assessed before treatment and six months post-treatment. In Study 1, DAI scores ranged from 0 to .73 (M = .23), with 47.7% of young adult participants exhibiting medium or high deficit burden. Higher DAI was associated with greater job problems, family disruption, sexual problems, and treatment side effects after adjusting for age and time since diagnosis (p's < .001). In Study 2, DAI scores ranged from 0 to .55 (M = .18), with 34.0% exhibiting medium or high deficit burden. Baseline DAI predicted worsening in hormonal functioning six months after treatment. Greater DAI was also associated with higher circulating interleukin-6 prior to treatment (p < .01). Across both cohorts, deficit accumulation functioned as a marker of survivorship burden; however, the specific outcomes associated with higher deficit burden differed across cohorts. Findings demonstrate the utility of the DAI as a multi-system metric for understanding vulnerability in cancer survivorship.

Indexed as

AgingProstatic NeoplasmsTesticular NeoplasmsAdolescentAdultAgedAged, 80 and overCancer SurvivorsCross-Sectional StudiesHumansLongitudinal StudiesMaleMiddle AgedYoung AdultAgingDeficit accumulation indexInflammationProstate cancerSurvivorshipTesticular cancer

Identifiers

PMID42068860
PMCPMC13198736

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.