Cardiovascular-specific PTH1R activation enhances exercise-induced cardiac remodeling in a mouse model of calcific atherosclerosis.

Andy Hon, Mimi Lu, Xuesi M Shao, Linda L Demer, Yin Tintut

Abstract read

In one paragraph

Article in Biochemical and biophysical research communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Andy HonDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

Mimi LuDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

Xuesi M ShaoDepartment of Neurobiology, University of California, Los Angeles, Los Angeles, CA, USA; Department of Internal Medicine, Charles R. Drew University of Medicine, Los Angeles, CA, USA.

Linda L DemerDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA; Department of Physiology, University of California, Los Angeles, Los Angeles, CA, USA.

Yin TintutDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; Department of Physiology, University of California, Los Angeles, Los Angeles, CA, USA; Department of Orthopaedic Surgery, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address: ytintut@mednet.ucla.edu.

Funding

Maternal inhaled nicotine leads to aberrant development of hypertensive phenotypeR01HL135623 · NHLBI · LOMA LINDA UNIVERSITY · PI SHAO, XUESI MAX, XIAO, DALIAO · 2017 to 2021

$2.3M

Role of intermittent activation of parathyroid hormone receptor in exercise-induced vascular calcificationR01HL151391 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DEMER, LINDA L., TINTUT, YIN · 2021 to 2024

$2.2M

NHLBI NIH HHS R01 HL135623NHLBI NIH HHS R01 HL151391

6 · The paper itself

Abstract

Exercise reduces cardiovascular events, yet its interactions with parathyroid hormone (PTH) and atherosclerotic calcification as well as their combined effects on cardiac remodeling remain unclear. Thus, we tested effects of constitutive activation of the PTH type I receptor (PTH1R) with and without exercise on aortic calcification and cardiovascular remodeling in a mouse model of atherosclerotic calcification. Female Ldlr

Indexed as

AtherosclerosisCalcinosisPhysical Conditioning, AnimalReceptor, Parathyroid Hormone, Type 1Vascular CalcificationVentricular RemodelingAnimalsDisease Models, AnimalFemaleMiceMice, Inbred C57BLMice, TransgenicReceptors, LDLPTH1R protein, mouseReceptor, Parathyroid Hormone, Type 1Receptors, LDLCardiac functionCTDiabetesPETVascular calcification

Identifiers

PMID42068751

DOI10.1016/j.bbrc.2026.153870

PMCPMC13664709

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.