Evidence map›Paper›PMID 42068575›Full record

ReviewEvolution & development2026

Internalized Evolutionary Inertia on Body Plan Evolution.

Wenxin Zeng, Naoki Irie

Abstract readReview
In one paragraph

Review in Evolution & development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Wenxin ZengDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan.ORCID 0009-0007-7880-2272
Naoki IrieResearch Center for Integrative Evolutionary Science, SOKENDAI, Hayama, Kanagawa, Japan.ORCID 0000-0002-6720-381X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the phenotypic diversity of animal species, the basic anatomical features, or body plan, of each animal phylum have been strictly conserved since their initial establishment in the early Cambrian. While this remarkable conservation could be explained by the conservation of the mid-embryonic phase (the developmental hourglass model) when the body plan is established, the underlying evolutionary mechanisms remained largely unclear. In this respect, recent studies have highlighted intrinsic properties in development, such as robustness, stability, and pleiotropic constraints, as potential contributors to its limitation of phenotypic diversifications. These findings suggest a potential mechanism of how phenotypic evolution is intrinsically limited or biased. In this review, potential developmental factors that contributed to the intrinsic limiting effects of animal embryogenesis against phenotypic diversification will be overviewed, with a particular focus on the general relationship between evolution and developmental processes.

Indexed as

Biological EvolutionBody PatterningInvertebratesVertebratesAnimalsEmbryonic DevelopmentPhenotypedevelopmental biasevolutionhourglass modelpleiotropic constraints

Identifiers

PMID42068575
PMCPMC13135384

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.