Evidence map›Paper›PMID 42068531›Full record

ArticleMolecular and cellular biochemistry2026

Polarized mitochondrial respiratory chain complexes in synaptic mitochondria induced by plasticity signals.

Xi Wang, Gang Zhou, Yi Hu, Kaiyuan Liu, Chong Zuo, Tingting Yan, Ji-Song Guan, Hong Xie

Abstract read
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Article in Molecular and cellular biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xi Wang *School of Artificial Intelligence Science and Technology & Institute of Photonic Chips, University of Shanghai for Science and Technology, Shanghai, 200093, China.
Gang Zhou *School of Life Science and Technology & State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, Shanghai, 201210, China.
Yi HuSchool of Artificial Intelligence Science and Technology & Institute of Photonic Chips, University of Shanghai for Science and Technology, Shanghai, 200093, China.
Kaiyuan LiuSchool of Artificial Intelligence Science and Technology & Institute of Photonic Chips, University of Shanghai for Science and Technology, Shanghai, 200093, China.
Chong ZuoSchool of Artificial Intelligence Science and Technology & Institute of Photonic Chips, University of Shanghai for Science and Technology, Shanghai, 200093, China.
Tingting YanSchool of Artificial Intelligence Science and Technology & Institute of Photonic Chips, University of Shanghai for Science and Technology, Shanghai, 200093, China.
Ji-Song GuanSchool of Life Science and Technology & State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, Shanghai, 201210, China.
Hong XieSchool of Artificial Intelligence Science and Technology & Institute of Photonic Chips, University of Shanghai for Science and Technology, Shanghai, 200093, China. hongxie@usst.edu.cn.

Funding

Central Guidance on Local Science and Technology Development Fund YDZX20233100001002National Natural Science Foundation of China 32130043Natural Science Foundation of Shanghai 25ZR1401269Scientific & Technological Innovation 2030 Major Project of China (No. 2021ZD203500), NSFC 32225023
6 · The paper itself

Abstract

Mitochondria are well established as key supporters of synaptic plasticity, yet the nanoscale spatial distribution of specific mitochondrial membrane proteins during this process remains poorly understood. Using 3D MINFLUX nanoscopy, we investigated their polarized distribution within synapses of cortical neurons undergoing chemical long-term potentiation (cLTP). Upon cLTP induction in DIV17 neurons, we observed an increased mitochondrial occupancy in stimulated synapses. Respiratory complexes of the inner mitochondrial membrane (IMM)-such as COX-IV and SDHA-showed a polarized accumulation near presynaptic sites, as validated by cluster analysis and 3D mapping. By contrast, outer mitochondrial membrane (OMM) proteins, including TOMM20 and VDAC, exhibited no significant polarized distribution. Together, these results demonstrate that cLTP selectively remodels the inner mitochondrial membrane to address localized energy requirements, highlighting the power of 3D MINFLUX for resolving protein organization with subcellular precision.

Indexed as

Long-Term PotentiationMitochondriaMitochondrial MembranesNeuronal PlasticityNeuronsSynapsesAnimalsMitochondrial Precursor Protein Import Complex ProteinsRatsMitochondrial Precursor Protein Import Complex ProteinsTomm20 protein, rat3D MINFLUX nanoscopyChemical long-term potentiationMitochondriaRespiratory chain complexSynaptic plasticity

Identifiers

PMID42068531

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.