Evidence map›Paper›PMID 42068527›Full record

ArticleJapanese journal of ophthalmology2026

Fibrotic response after Baerveldt glaucoma drainage device surgery: an initial sight-threatening sign in eyes with refractory childhood glaucoma.

Rumi Kawashima, Kenji Matsushita, Masako Kurashige, Takahiro Matsui, Yuichi Motoyama, Takahiro Fujino, Eiichi Morii, Kohji Nishida

Abstract read
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In one paragraph

Article in Japanese journal of ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rumi KawashimaDepartment of Ophthalmology, Graduate School of Medicine, The University of Osaka, Yamadaoka 2-2, Suita, Osaka, 565-0871, Japan.
Kenji MatsushitaDepartment of Ophthalmology, Graduate School of Medicine, The University of Osaka, Yamadaoka 2-2, Suita, Osaka, 565-0871, Japan. kenmatsu@ophthal.med.osaka-u.ac.jp.ORCID http://orcid.org/0000-0002-0418-6696
Masako KurashigeDepartment of Pathology, Graduate School of Medicine, The University of Osaka, Osaka, Japan.
Takahiro MatsuiDepartment of Pathology, Graduate School of Medicine, The University of Osaka, Osaka, Japan.
Yuichi MotoyamaDepartment of Pathology, Graduate School of Medicine, The University of Osaka, Osaka, Japan.
Takahiro FujinoDepartment of Ophthalmology, Graduate School of Medicine, The University of Osaka, Yamadaoka 2-2, Suita, Osaka, 565-0871, Japan.
Eiichi MoriiIntegrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, The University of Osaka, Osaka, Japan.
Kohji NishidaDepartment of Ophthalmology, Graduate School of Medicine, The University of Osaka, Yamadaoka 2-2, Suita, Osaka, 565-0871, Japan.

Funding

Japan Agency for Medical Research and Development J229013004Japan Agency for Medical Research and Development J250705005Japan Agency for Medical Research and Development JP25ek0109798JSPS KAKENHI 18K09406JSPS KAKENHI 20K18379JSPS KAKENHI 24K12782JSPS KAKENHI 24K19809
6 · The paper itself

Abstract

purposeWe report the pathological analysis of a postoperative fibrotic reaction as an initial sign of a sight-threatening complication observed during the 2-year outcomes follow up of Baerveldt glaucoma implant (BGI) surgery in eyes with refractory childhood glaucoma. STUDY

designRetrospective case series.

methodsFifteen eyes of 10 patients with refractory childhood glaucoma underwent BGI surgery between 2013 and 2020 at the University of Osaka Hospital. Patients were followed for a minimum of 2 years postoperatively. We investigated the postoperative complications, and histopathologically analyzed the specimens obtained from three eyes with postoperative fibrous membranes on the irises.

resultsNine eyes (60%) had a postoperative fibrous membrane around the tube or on the iris close to the tube, whereas two eyes developed a tractional retinal detachment. The pathological results indicated the tissues were eosinophilic fibrous scar tissues that did not have inflammatory or neoplastic lesions.

conclusionBGI surgery was effective in patients with refractory childhood glaucoma. However, clinicians should be alert to the potential for development of fibrotic ocular inflammation in refractory childhood glaucoma eyes.

Indexed as

GlaucomaGlaucoma Drainage ImplantsIntraocular PressurePostoperative ComplicationsVisual AcuityAdolescentChildChild, PreschoolFemaleFibrosisFollow-Up StudiesHumansInfantMaleRetrospective StudiesBaerveldt glaucoma implantChildhood glaucomaFibrosisRefractory glaucoma

Identifiers

PMID42068527
PMCPMC13452745

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.