ArticleBiological trace element research2026
Ameliorative Effect of Green Bimetallic Zinc Oxide-Magnesium Oxide Nanoparticles Against Gastric Ulcer in Rats via Modulation of Oxidative Stress, Inflammatory Cascades, Nrf2/NF-κB Signaling, Angiogenic VEGF Expression.
Article in Biological trace element research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Gastric ulcers are a highly prevalent gastrointestinal disorder, impacting a significant portion of the global population, and have serious complications, such as bleeding, perforation, and malignant transformation. The ethanol-induced gastric ulcer model provides a distinct advantage because it faithfully mimics clinical features seen in acute peptic ulcer disease. This study aimed to evaluate the effect of bimetallic zinc oxide-magnesium oxide nanoparticles (ZnO-MgO NPs) on ethanol-induced gastric ulcer in albino rats. Different monometallic and bimetallic NPs have been completely characterized and synthesized by an eco-friendly and cost-effective method utilizing Gum Arabic as a strong reducing agent. Fifty rats were divided into five groups: control, ethanol-induced gastric ulcer, ulcerated rats treated daily for 14 days with ZnO NPs, MgO NPs, or bimetallic ZnO-MgO NPs. Rat's stomachs underwent biochemical estimation for catalase (CAT), superoxide dismutase (SOD), Malondialdehyde (MDA), Nuclear factor erythroid 2-related factor 2 (Nrf2), Nuclear factor kappa b (NF-κB), and Tumor necrosis factor alpha (TNF-α), as well as, histological, immunohistochemical (including Vascular endothelial growth factor, VEGF, and Inducible nitric oxide synthase, iNOS), and Scanning electron microscopic examinations. The synthesized monometallic and bimetallic NPs had a semi-spherical shape, with an average diameter of 40.44 ± 1.3 nm (for ZnO NPs), 35.56 ± 1.2 nm (for MgO NPs) and 48.46 ± 1.5 nm (for ZnO-MgO NPs). In alcohol-induced gastric ulcer group, ulceration with a significant increase in histopathological changes was noticed in the form of ulceration, inflammatory infiltrations, activated mast cells, edema, and hemorrhage. Decrease activities of CAT, SOD, and Nrf2, as well as an increase in MDA, TNF-α, and NF-κB, with upregulation of iNOS, and downregulation of VEGF, which were improved partially by treatment of either ZnO NPs or MgO NPs. ZnO-MgO NPs restored the normal histological picture of the rat's stomach. Bimetallic ZnO-MgO NPs have a more powerful curative effect than each one of ZnO NPs or MgO NPs; separately, which can be explained by the synergetic effect of them leading to more potent antioxidant and anti-inflammatory effects.
Indexed as
Identifiers
42068518What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.