Evidence map›Paper›PMID 42068443›Full record

ReviewWorld journal of microbiology & biotechnology2026

Dismantling darkness: interdisciplinary perspectives on melanin degradation.

Lucas Martins Alcântara, Camilla de Oliveira Alves, Elisa Gonçalves Medeiros, Deborah Santos Cintra, Kamilla Xavier Gomes, Yasmim Cristina de Almeida Lima, Susana Frases, Marcia Ribeiro Pinto, Radamés Jb Cordero, Allan Jefferson Guimarães

Abstract readReview
In one paragraph

Review in World journal of microbiology & biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lucas Martins AlcântaraLaboratório de Bioquímica e Imunologia das Micoses, Instituto Biomédico, Fluminense Federal University, Niterói, Brazil.
Camilla de Oliveira AlvesLaboratório de Bioquímica e Imunologia das Micoses, Instituto Biomédico, Fluminense Federal University, Niterói, Brazil.
Elisa Gonçalves MedeirosLaboratório de Bioquímica e Imunologia das Micoses, Instituto Biomédico, Fluminense Federal University, Niterói, Brazil.
Deborah Santos CintraLaboratório de Bioquímica e Imunologia das Micoses, Instituto Biomédico, Fluminense Federal University, Niterói, Brazil.
Kamilla Xavier GomesLaboratório de Bioquímica e Imunologia das Micoses, Instituto Biomédico, Fluminense Federal University, Niterói, Brazil.
Yasmim Cristina de Almeida LimaLaboratório de Bioquímica e Imunologia das Micoses, Instituto Biomédico, Fluminense Federal University, Niterói, Brazil.
Susana FrasesLaboratório de Biologia de Fungos, Instituto de Biofísica Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Marcia Ribeiro PintoLaboratório de Bioquímica e Imunologia das Micoses, Instituto Biomédico, Fluminense Federal University, Niterói, Brazil.
Radamés Jb CorderoDepartment of Molecular Microbiology and Immunology, Johns Hopkins University, Baltimore, USA.
Allan Jefferson GuimarãesLaboratório de Bioquímica e Imunologia das Micoses, Instituto Biomédico, Fluminense Federal University, Niterói, Brazil. allanguimaraes@id.uff.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microbial melanins are exceptionally recalcitrant biopolymers that facilitate fungal virulence and biodeterioration. This review synthesizes physical, chemical, and biological degradation strategies for major microbial melanin categories, aligning technical mechanisms with their translational potential. While physical methods such as ultrasound-assisted (UAE) and microwave-assisted extraction (MAE) function as matrix-disrupting pretreatments rather than standalone degradation strategies, chemical approaches remain the analytical standard for structural fingerprinting via specific markers like pyrrole-2,3,5-tricarboxylic acid (PTCA), pyrrole-2,3-dicarboxylic acid (PDCA) and 4-amino-3-hydroxyphenylalanine (AHP). Conversely, biological approaches, primarily utilizing ligninolytic enzymes such as laccases and peroxidases that catalyze the oxidative breakdown of complex melanin structures, offer the most sustainable route for applied degradation. We critically evaluate emerging biotechnological solutions, including immobilized nanobiocatalysts like LiP@MFO-GO (LiP immobilized onto graphene oxide coated magnetic nanoparticles), engineered synergistic laccase-peroxidase complexes for in situ H

Indexed as

MelaninsBiodegradation, EnvironmentalBiotechnologyFungiHydrogen PeroxideLaccaseOxidation-ReductionPeroxidasesHydrogen PeroxideLaccaseMelaninsPeroxidasesBioremediationDegradationDHN-melaninLaccaseLignin PeroxidaseManganese PeroxidaseMicrobial Melanin

Identifiers

PMID42068443
PMCPMC13135606

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.