ArticleAnalytical and bioanalytical chemistry2026
Screening-confirmation approach for urinary alpelisib by silver-nanorod enabled portable SERS platform and LC-MS validation.
Article in Analytical and bioanalytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Nanomaterial-enabled bioanalytical sensing for doping detection: a critical review of signal transduction, matrix effects, and translation barriers.Analytical and bioanalytical chemistry · 2026Review
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Authors and funding
4 authors.
Funding
Abstract
Alpelisib, a selective PI3Kα inhibitor, benefits from reliable quantitative measurements to support exposure assessment and dose individualization. Here, we report a portable surface-enhanced Raman spectroscopy (SERS) workflow for rapid urinary screening and quantification of alpelisib using shaped-controlled silver nanoparticles, with silver nanorods selected as the substrate providing the highest SERS response among spherical, cubic, and rod-like morphologies. Key substrate-preparation and instrumental parameters were systematically optimized using a portable 785-nm Raman device, and the analytical figures of merit were thoroughly assessed in urine following a sample clean-up by protein precipitation and liquid-liquid extraction. Under optimized conditions, the diagnostic band at 993 cm⁻
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Registered trials
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