ArticleAnalytical chemistry2026
Electrospray Regime Controls Sensitivity and Quantitative Performance in Micro- and Nano-Flow CE-ESI-MS.
Article in Analytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Aspiration Patch Proteomics Enables CE-ESI-MS Proteotyping of Identified Single Neurons in Intact Brain Tissue.Analytical chemistry · 2026Article
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Authors and funding
3 authors.
Funding
Abstract
The electrospray regime is a key determinant of ion formation during electrospray ionization (ESI), but it is often unreported and rarely verified in separation-coupled mass spectrometry (MS) workflows. In capillary electrophoresis (CE)-mass spectrometry (CE-ESI-MS), sheath-flow microflow ESI interfaces are widely used for metabolite analysis, whereas nanoflow ESI interfaces dominate peptide and protein measurements. Here, we benchmarked CE-ESI-MS performance in the cone-jet (CJ) and pulsating (P) regimes for trace-level metabolites, peptides, and proteome digests across microflow (μESI) and nanoflow (nanoESI) operation. In CE-μESI on a time-of-flight mass spectrometer, CJ increased metabolite sensitivity by up to ∼2-fold, improved signal stability, and shifted peptide ion generation to higher charge states relative to P. In CE-nanoESI proteomics on a timsTOF platform, CJ increased HeLa peptide and protein identifications by ∼50% and extended coverage to lower-abundance proteins while improving quantification completeness across technical replicates (i.e., a higher fraction of proteins quantified in all runs). For
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Registered trials
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