Evidence map›Paper›PMID 42068189›Full record

ReviewAdvanced healthcare materials2026

A Data Driven Review of In Vitro Electrical and Mechanical Stimulation for Post-Acute Phase Wound Healing.

Matthew K Burgess, Ellen F Marsh, Veronica M Lucian, Malavika Nair

Abstract readReview
In one paragraph

Review in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Matthew K BurgessInstitute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UK.ORCID https://orcid.org/0009-0004-9027-6154
Ellen F MarshInstitute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UK.ORCID https://orcid.org/0009-0005-6638-4240
Veronica M LucianInstitute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0002-2242-5494
Malavika NairInstitute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0002-5229-8991

Funding

BBSRCEngineering and Physical Sciences Research Council EP/W524311/1Engineering and Physical Sciences Research Council EP/Y004434/1Engineering and Physical Sciences Research Council EP/Y034791/1Rhodes Scholarships
6 · The paper itself

Abstract

This review explores the role of in vitro electrical and mechanical stimulation in modulating wound-healing behavior, with a primary focus on the predominant skin cell types: fibroblasts and keratinocytes. By analyzing the existing literature, we delineate the complex relationships between stimulation parameters-such as voltage, current, frequency, and mechanical strain-and cellular responses, including proliferation and migration. Our data-driven approach compiled more than 390 experimental data points for electrical stimulation and over 170 for mechanical stimulation in vitro, constructing a comprehensive library of cell responses that were previously fragmented and difficult to compare across studies. We critically evaluate various stimulation platforms and configurations, emphasizing their influence on cellular mechanobiology and their translational potential in regenerative medicine. Ultimately, this review underscores the necessity of a multi-parameter optimization strategy to effectively exploit electromechanical cues for targeted skin tissue regeneration.

Indexed as

Electric StimulationWound HealingAnimalsCell MovementCell ProliferationFibroblastsHumansKeratinocytesSkinStress, Mechanicalelectrical stimulationfibroblastskeratinocytesmechanical stimulationwound healing

Identifiers

PMID42068189
PMCPMC13279864

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.