ArticlePsychiatry and clinical neurosciences2026
Neurochemically informed network control theory reveals energetic dysregulation of altered brain state dynamics in obsessive-compulsive disorder.
Article in Psychiatry and clinical neurosciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
aimPrevious studies assessed dynamic functional connectivity in obsessive-compulsive disorder (OCD) by the sliding-window approach, limiting sensitivity to rapid neural fluctuations. Moreover, the mechanisms underlying dynamic transitions between brain states also remain unknown. Therefore, the study aimed to explore the dynamic neural mechanisms of OCD by characterizing state dynamic patterns and the underlying energy basis.
methodsThe study recruited 198 OCD patients and 109 healthy controls, characterizing altered state dynamic patterns and underlying control energy in OCD by integrating co-activation pattern (CAP) analysis with network control theory (NCT).
resultsOCD patients showed increased occurrences of the states characterized by ventral attention and somatomotor network co-activation with default mode network suppression (VAN-SMN
conclusionsOCD is characterized by a maladaptive brain-state cycle marked by excessive DMN dominance, frequent shifts to VAN/SMN activation states, and attenuated FPN engagement. Computationally enhancing the persistence of the FPN
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