ArticleActa obstetricia et gynecologica Scandinavica2026
The TRUFFLE monitoring protocol for early-onset fetal growth restriction: A clinical effectiveness study.
Article in Acta obstetricia et gynecologica Scandinavica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- The TRUFFLE monitoring protocol for early-onset fetal growth restriction: A clinical effectiveness study.Acta obstetricia et gynecologica Scandinavica · 2026Article
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7 authors.
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Abstract
introductionThe randomized control Trial (RCT) of Randomized Umbilical and Fetal Flow in Europe (TRUFFLE study) established its clinical efficacy for monitoring preterm fetal growth restriction (FGR). The objective of this study was to assess the clinical effectiveness of this protocol in a routine clinical setting with regards to the clinical outcomes, both overall and stratified by gestational age at FGR diagnosis. MATERIAL AND
methodsThis is a retrospective cohort study of singleton pregnancies with preterm FGR between January 2013 and July 2024 in a tertiary Fetal Medicine Unit. FGR was defined as an estimated fetal weight or abdominal circumference <10th centile with an elevated umbilical artery pulsatility index >95th centile. Main outcomes collected included perinatal survival, interval from diagnosis to delivery, and delivery indications.
results171 pregnancies met inclusion criteria. The median (IQR) gestation at FGR diagnosis and birth was 27
conclusionsThe TRUFFLE monitoring protocol is clinically effective in managing early-onset FGR outside a trial environment, achieving comparable perinatal outcomes to the original RCT. Routine integration of both Doppler and cCTG monitoring is crucial for optimal timing of birth with early FGR. Further research is needed to explore the benefits of more frequent or remote fetal monitoring.
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