Evidence map›Paper›PMID 42067961›Full record

ReviewCell proliferation2026

Next-Generation Strategies for Neural Repair and Regeneration: Neural Organoid Transplantation in the CNS.

Yutong Wang, Jinrui Li, Xingjia Mao, Wanyu Wang, Yansong Li, Xuefei Hu, Jinjie Zhong, Fengdong Zhao, Linlin Wang

Abstract readReview
In one paragraph

Review in Cell proliferation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yutong WangDepartment of Orthopaedics of Sir Run Run Shaw Hospital, and Department of Basic Medicine Sciences, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Jinrui LiDepartment of Orthopaedics of Sir Run Run Shaw Hospital, and Department of Basic Medicine Sciences, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Xingjia MaoDepartment of Orthopaedics of Sir Run Run Shaw Hospital, and Department of Basic Medicine Sciences, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Wanyu WangDepartment of Neurosurgery, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Yansong LiSchool of Clinical Medicine, the Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, China.
Xuefei HuDepartment of Basic Medicine Sciences, Tarim University, Aral, People's Republic of China.
Jinjie ZhongDepartment of Obstetrics of the Second Affiliated Hospital, and Department of Basic Medicine Sciences, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Fengdong ZhaoDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Linlin WangDepartment of Orthopaedics of Sir Run Run Shaw Hospital, and Department of Basic Medicine Sciences, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.ORCID https://orcid.org/0000-0002-7720-3012

Funding

National Natural Science Foundation of China 82172527Natural Science Foundation of Zhejiang Province LZ26H090001
6 · The paper itself

Abstract

Neurological disorders are often devastating and notoriously difficult to repair, creating an urgent need for novel research models and therapeutic strategies. Neural organoids-three-dimensional, self-assembling structures derived from stem cells-have emerged as a powerful platform to address this challenge. Supported by enabling technologies like bioreactors and 3D printing, advanced maturation protocols have significantly enhanced their cellular diversity and functional utility. This progress has paved the way for their widespread application in developmental studies, disease modelling, and notably, regenerative medicine. Focusing specifically on the latter, this article reviews how neural organoid transplantation opens new avenues for treating CNS injuries and degeneration. We first elaborate on the development, characteristics, and maturation strategies of neural organoids. We then summarise the translational applications and achievements of transplanting both whole neural organoids and their derived vesicles, analyse the prevailing challenges in the field, and finally, outline future directions to advance the therapeutic potential of this technology.

Indexed as

Central Nervous SystemNerve RegenerationNeuronsOrganoidsAnimalsHumansNeural Stem CellsRegenerative Medicinecharacteristicsmaturationneural organoidsrepair and regenerationtransplantation

Identifiers

PMID42067961
PMCPMC13241826

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.