Evidence map›Paper›PMID 42067931›Full record

ArticleRespiratory research2026

Qualitative beta-2-adrenoceptor signaling in the regulation of human airway epithelia mucin and cytokine production.

Fred Graumuller, Diana Cervantes, Tung O Chan, Niccolette Schaunaman, Dominic R Villalba, Burton F Dickey, Julia K L Walker, Hong Wei Chu, Raymond B Penn

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fred Graumuller *Department of Medicine, Pulmonary and Critical Care Medicine, Center for Translational Medicine, Jane and Leonard Korman Respiratory Institute, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
Diana Cervantes *Department of Medicine, National Jewish Health, Denver, CO, 80206, USA.
Tung O ChanDepartment of Medicine, Pulmonary and Critical Care Medicine, Center for Translational Medicine, Jane and Leonard Korman Respiratory Institute, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
Niccolette SchaunamanDepartment of Medicine, National Jewish Health, Denver, CO, 80206, USA.
Dominic R VillalbaDepartment of Medicine, Pulmonary and Critical Care Medicine, Center for Translational Medicine, Jane and Leonard Korman Respiratory Institute, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
Burton F DickeyDepartment of Pulmonary Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Julia K L WalkerDepartment of Medicine and School of Nursing, Duke University Medical Center, Durham, NC, USA.
Hong Wei ChuDepartment of Medicine, National Jewish Health, Denver, CO, 80206, USA.
Raymond B PennDepartment of Medicine, Pulmonary and Critical Care Medicine, Center for Translational Medicine, Jane and Leonard Korman Respiratory Institute, Thomas Jefferson University, Philadelphia, PA, 19107, USA. raymond.penn@jefferson.edu.

Funding

Strategies for biasing and augmenting b2-adrenoceptor signaling and function in ASMP01HL180318 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI RAYMOND B. PENN · 2025 to 2026
$7.1M
Optimizing Beta-Adrenoceptor Signaling Bias in AsthmaR01AI110007 · NIAID · DUKE UNIVERSITY · PI BOND, RICHARD AGUSTIN, PENN, RAYMOND B. · 2014 to 2018
$3.2M
NHLBI NIH HHS P01 HL180318NIAID NIH HHS R01 AI110007NIH HHS NIH NIAID R01AI16129
6 · The paper itself

Abstract

backgroundNumerous in vivo studies have demonstrated beta-2-adrenoceptor (β

methodsTo explore the potential contribution of airway epithelia in this phenomenon, we compared the ability of ractopamine (RP), recently identified as a Gs-biased beta-agonist, to that of the unbiased/balanced beta-agonist albuterol (ALB), on IL-13-stimulated mucin and cytokine production in human airway epithelia cultures in air-liquid interface (HAE).

resultsALB, which activates both the β

conclusionsThese data implicate arrestin-dependent β

Indexed as

CytokinesMucinsReceptors, Adrenergic, beta-2Respiratory MucosaSignal TransductionAdrenergic beta-2 Receptor AgonistsAlbuterolCells, CulturedHumansInterleukin-13Adrenergic beta-2 Receptor AgonistsAlbuterolCytokinesInterleukin-13MucinsReceptors, Adrenergic, beta-2AsthmaBeta-arrestinBiased signalingG proteinInflammationProtein kinase A

Identifiers

PMID42067931
PMCPMC13312746

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.