Evidence map›Paper›PMID 42067914›Full record

ArticleEnvironmental health : a global access science source2026

In utero and childhood exposure to organochlorines and perfluorinated chemicals in relation to sperm aneuploidy in adulthood.

Melissa J Perry, Alessandra Meddis, Heather A Young, C Rebecca Robbins, Esben Budtz-Jørgensen, Niels Jørgensen, Jónrit Halling, Pál Weihe, Philippe Grandjean, Maria Skaalum Petersen

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Article in Environmental health : a global access science source, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Melissa J PerryOffice of the Dean and Department of Global and Community Health, College of Public Health, George Mason University, Fairfax, VA, USA. mperry27@gmu.edu.
Alessandra MeddisDepartment of Public Health, Section of Biostatistics, Copenhagen University, Copenhagen, DK, Denmark.
Heather A YoungDepartment of Epidemiology, Milken Institute School of Public Health, The George Washington University, Washington, DC, USA.
C Rebecca RobbinsDepartment of Environmental and Occupational Health, Milken Institute School of Public Health, The George Washington University, Washington, DC, USA.
Esben Budtz-JørgensenDepartment of Public Health, Section of Biostatistics, Copenhagen University, Copenhagen, DK, Denmark.
Niels JørgensenDepartment of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet and International Centre for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen, Denmark.
Jónrit HallingDepartment of Research, the National Hospital of the Faroe Islands, Tórshavn, Faroe Islands.
Pál WeiheCentre of Health Science, Faculty of Health Sciences, University of the Faroe Islands, Tórshavn, Faroe Islands.
Philippe GrandjeanNational Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.
Maria Skaalum PetersenDepartment of Research, the National Hospital of the Faroe Islands, Tórshavn, Faroe Islands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSperm chromosomal abnormalities are linked to infertility and may be caused by endocrine disrupting chemical exposures during development.

objectivesWe examined whether exposure to organochlorine compounds (OC), including polychlorinated compounds (PCBs), and perfluorinated compounds (PFASs) measured repeatedly since birth predicted sperm chromosomal abnormalities in young adulthood.

methodsAneuploidy was determined in semen samples obtained from 96 Faroese young men aged 22-24 years who were members of a birth cohort created in 1986-1987. Their current and previous serum as well as cord blood were analyzed for DDE, major PCB congeners (118, 138, 153, and 180), and PFAS (PFOA, PFOS, PFNA, PFDA, and PFHxS). Incidence rate ratios between the exposures and the risk of an extra sex chromosome in adult sperm were assessed as indication of meiotic errors. The mixture effect for overall exposures (PCBs and/or PFASs) was estimated as the change in the percentage of each type of disomy for a doubling of the exposures for two individuals within the same smoking status and abstinence time group.

resultsHigher concentrations of organochlorines in cord blood and in serum at ages 7, 14 years and 22 years were associated with increased proportions of chromosomal disomies. The PCB concentration in cord blood was associated mainly with having an extra Y chromosome (p-value: 0.006), while PFAS concentrations at adulthood were consistently associated with XX18 and YY18 disomies (p-values < 0.05). DISCUSSION: These findings provide new evidence that fetal and subsequent chemical exposures can have enduring influence into adulthood on the formation of male germ cells.

Indexed as

AneuploidyEnvironmental ExposureEnvironmental PollutantsFluorocarbonsHydrocarbons, ChlorinatedPrenatal Exposure Delayed EffectsSpermatozoaFetal BloodHumansMalePolychlorinated BiphenylsPregnancyYoung AdultEnvironmental PollutantsFluorocarbonsHydrocarbons, ChlorinatedPolychlorinated Biphenyls

Identifiers

PMID42067914
PMCPMC13281659

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