Observational studyBMC musculoskeletal disorders2026
The relationship between exposure to long-term training, neuromuscular function and muscular structure in adolescents with cerebral palsy and typically-developed peers: a cross-sectional follow-up analysis.
Observational study in BMC musculoskeletal disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05859360 (Functional Exercise Training With Adolescents and Young Adults With Cerebral Palsy), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Functional Exercise Training With Adolescents and Young Adults With Cerebral Palsy: Follow Up Study
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Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis cross-sectional study examined whether exposure to long-term resistance and endurance training can counteract muscular weakness on a functional, neurological and structural level in adolescents with cerebral palsy (CP) compared to typically-developed peers (TD) depending on training status.
methodsFive trained (4 males; mean age: 19.8) and four untrained adolescents with CP (3 males; 20.2) were compared to nine age- and sex-matched TD trained (7 males; 19.8) and nine untrained peers (7 males; 20.3). Isometric and isokinetic measurements assessed strength in knee flexion and extension, voluntary activation (VA) was assessed using the twitch interpolation technique and ultrasound imaging of the quadriceps was performed to assess anatomical cross-sectional area (ACSA) and architecture.
resultsLinear regression models revealed that CP trained had lower absolute isometric strength (dominant: -18% [-48; 11]; non-dominant: -35% [-58; -11]) than TD untrained while CP untrained showed between 29% and 33% lower strength than TD untrained. VA in CP trained (dominant: -13% [-23; -3]; non-dominant: -10% [-30; 11]) and CP untrained (dominant: -14% [-23; -4]; non-dominant: -8% [-29; 13]) showed similar deficits compared to TD untrained. CP trained showed higher ACSA than TD untrained in the dominant leg of the vastus lateralis muscle (+ 16% [-7; 38]), while the non-dominant side showed lower values (-18% [-45; 9]).
conclusionExposure to long-term resistance and endurance training is associated with a reduced gap in muscle strength and muscle volume in the dominant leg of adolescents with CP while neural drive does not seem to be affected through training exposure. It is discussed that training load might have been too low in the non-dominant leg of CP trained to induce relevant neuromuscular adaptations.
trial registrationClinicalTrials.gov Identifier NCT05859360, date of registration May 16, 2023.
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