Observational studyBMC cancer2026
Monocyte engraftment dynamics and flow cytometric analysis in allogeneic and autologous peripheral blood stem cell transplantation: a prospective study.
Observational study in BMC cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHematopoietic stem cell transplantation (HSCT) success relies on timely engraftment and immune reconstitution. While neutrophil and platelet recovery are well-established clinical endpoints, the dynamics of monocyte engraftment and their relationship with hematopoietic recovery remain insufficiently characterized.
methodsIn this prospective observational study, 56 patients undergoing autologous (n = 32) or allogeneic (n = 24) peripheral blood stem cell transplantation were enrolled. Pre-engraftment monocyte peak day was defined based on serial complete blood counts. Flow cytometric analysis was performed at the time of monocyte engraftment to assess monocyte (CD14/CD16) and lymphocyte subsets. Associations between monocyte dynamics and neutrophil and platelet engraftment were evaluated using correlation and multivariable regression analyses.
resultsAllogeneic recipients demonstrated significantly delayed neutrophil engraftment compared to autologous patients (p=0.003). Pre-engraftment monocyte peak day was strongly correlated with neutrophil engraftment (ρ = 0.83, p < 0.001) and moderately correlated with platelet engraftment (ρ = 0.46, p = 0.001). In multivariable analyses, monocyte peak timing remained independently associated with both neutrophil (B = 0.87, p < 0.001) and platelet recovery (B = 1.53, p = 0.015), whereas CD34⁺ cell dose showed no independent association. Flow cytometric analysis demonstrated predominance of CD14⁺ monocytes during early engraftment. Despite elevated inflammatory markers in patients with complications, engraftment kinetics remained comparable.
conclusionsPre-engraftment monocyte dynamics are strongly associated with subsequent hematopoietic recovery and may serve as an early indicator of engraftment following HSCT. These findings support the potential utility of monocyte-based monitoring in post-transplant care and highlight the need for further studies to validate their prognostic value.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.