Evidence map›Paper›PMID 42067843›Full record

ArticleRespiratory research2026

Blood eosinophil counts and postoperative outcomes in early-stage lung cancer: a retrospective cohort study.

Everglad Mugutso, Ophir Freund, Isabelle Pitrou, Ankita Ghatak, Cédric Roux, Samantha Jacobson, Jonathan-Raphaël Stetco, Sara Kutzkel, Amir Bar-Shai, Benjamin Smith and 1 more

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Article in Respiratory research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Everglad MugutsoResearch Institute McGill University Health Centre, Centre for Outcomes Research and Evaluation (CORE), 5252 De Maisonneuve, Montreal, QC, H4A 3S9, Canada.
Ophir FreundTel-Aviv Sourasky Medical Center and Faculty of Medicine, The Institute of Pulmonary MedicineTel-Aviv University, Tel Aviv, Israel.
Isabelle PitrouResearch Institute McGill University Health Centre, Centre for Outcomes Research and Evaluation (CORE), 5252 De Maisonneuve, Montreal, QC, H4A 3S9, Canada.
Ankita GhatakResearch Institute McGill University Health Centre, Centre for Outcomes Research and Evaluation (CORE), 5252 De Maisonneuve, Montreal, QC, H4A 3S9, Canada.
Cédric RouxBioinformatics Department, Research Institute McGill University Health Centre, Montreal, QC, Canada.
Samantha JacobsonUniversity of Sherbrooke, Faculty of Medicine and Health SciencesSherbrooke, QC, Canada.
Jonathan-Raphaël StetcoUniversity of Sherbrooke, Faculty of Medicine and Health SciencesSherbrooke, QC, Canada.
Sara KutzkelTel-Aviv Sourasky Medical Center and Faculty of Medicine, The Institute of Pulmonary MedicineTel-Aviv University, Tel Aviv, Israel.
Amir Bar-ShaiTel-Aviv Sourasky Medical Center and Faculty of Medicine, The Institute of Pulmonary MedicineTel-Aviv University, Tel Aviv, Israel.
Benjamin SmithResearch Institute McGill University Health Centre, Centre for Outcomes Research and Evaluation (CORE), 5252 De Maisonneuve, Montreal, QC, H4A 3S9, Canada.
Nicole EzerResearch Institute McGill University Health Centre, Centre for Outcomes Research and Evaluation (CORE), 5252 De Maisonneuve, Montreal, QC, H4A 3S9, Canada. nicole.ezer@mcgill.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLung cancer resection is curative but associated with postoperative morbidity and mortality. This study evaluated whether elevated blood eosinophil count (BEC) was associated with postoperative outcomes in early-stage lung cancer.

methodsThis was a retrospective cohort study of consecutive adult patients undergoing lung resection for stage I and II non-small cell lung cancer in a large tertiary referral center from September 2017 to June 2021. Data were drawn from the institution's Data Warehouse. The primary outcome was 90-day healthcare utilization defined as emergency department visit or hospital readmission. Secondary outcomes were postoperative complications, index hospitalization length of stay, and 1-year survival. Preoperative 90-day BEC was categorized by a threshold of 200 cells/µL. Covariates were age, sex, smoking status, Charlson Comorbidity Index, chronic obstructive pulmonary disease (COPD), asthma, tumor size, nodal status, surgical approach, and blood results (white blood cells, hemoglobin, and creatinine). The main analyses were validated by a second international cohort. Log-Poisson with robust variance estimation and Cox proportional hazards regression models were fit for primary and secondary outcomes. Analyses were replicated for BEC thresholds of 150 and 300 cells/µL.

resultsAmong 715 patients undergoing lung resection (median age = 69 years, 42% male, 29% with COPD), 146 patients (20%) had high preoperative BEC ≥ 200 cells/µL. BEC ≥ 200 cells/µL was associated with a higher rate of 90-day healthcare utilization:19% vs. 14% for BEC < 200 cells/µL. This association remained after adjustment (Risk Ratio [RR], 1.52; 95% Confidence Interval [CI], 1.02-2.25) and the validation cohort (RR, 2.23; 95% CI, 1.06-4.69). BEC as a continuous measure was also associated with the primary outcome in both cohorts: RR, 2.15 (95% CI, 1.49-3.12) and RR, 1.42 (95% CI, 1.10-1.94), respectively. BEC ≥ 200 cells/µL was associated with higher probability of death 1 year post-surgery (adjusted Hazard Ratio, 2.41; 95% CI, 1.08-5.35). There was no difference in the risk of postoperative pulmonary complications between high and low BEC (RR, 0.86; 95% CI, 0.58-1.27).

conclusionsElevated preoperative BEC was associated with higher risk of postoperative healthcare utilization and lower 1-year survival after lung cancer resection among patients with or without respiratory disease.

Indexed as

Carcinoma, Non-Small-Cell LungEosinophilsLung NeoplasmsPneumonectomyPostoperative ComplicationsAgedCohort StudiesFemaleHumansLeukocyte CountMaleMiddle AgedNeoplasm StagingRetrospective StudiesTreatment OutcomeBlood eosinophil countsChronic obstructive pulmonary diseaseHealthcare utilizationInhaled corticosteroidsLung cancerNon-small cell lung cancerOutcomesThoracic surgery

Identifiers

PMID42067843
PMCPMC13289531

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.