Evidence map›Paper›PMID 42067826›Full record

ArticleBMC gastroenterology2026

Improvement of hepatic reserve and changes in liver and spleen volume after balloon-occluded retrograde transvenous obliteration.

Kazuma Shinkai, Ryotaro Sakamori, Ryoko Yamada, Yuki Tahata, Kazuki Maesaka, Kengo Matsumoto, Yasutoshi Nozaki, Seiichi Tawara, Hisashi Ishida, Yuichi Yoshida and 14 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Kazuma ShinkaiDepartment of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Ryotaro SakamoriDepartment of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Ryoko YamadaDepartment of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Yuki TahataDepartment of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Kazuki MaesakaDepartment of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Kengo MatsumotoToyonaka Municipal Hospital, Toyonaka, Osaka, Japan.
Yasutoshi NozakiKansai Rosai Hospital, Amagasaki, Hyogo, Japan.
Seiichi TawaraOsaka General Medical Center, Osaka, Osaka, Japan.
Hisashi IshidaIkeda Municipal Hospital, Ikeda, Osaka, Japan.
Yuichi YoshidaSuita Municipal Hospital, Suita, Osaka, Japan.
Satoshi TanakaNHO Osaka National Hospital, Osaka, Osaka, Japan.
Toshifumi ItoJapan Community Health Care Organization Osaka Hospital, Osaka, Osaka, Japan.
Yoshinori DoiKKR Otemae Hospital, Osaka, Osaka, Japan.
Sadaharu IioHyogo Prefectural Nishinomiya Hospital, Nishinomiya, Hyogo, Japan.
Mitsuru SakakibaraYao Municipal Hospital, Yao, Osaka, Japan.
Fumihiko NakanishiNational Hospital Organization Osaka Minami Medical Center, Kawachinagano, Osaka, Japan.
Kazuhiro MuraiDepartment of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Yoshinobu SaitoDepartment of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Akira NishioDepartment of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Kunimaro FurutaDepartment of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Takahiro KodamaDepartment of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Hayato HikitaDepartment of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Tomohide TatsumiDepartment of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Tetsuo TakeharaDepartment of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. takehara@gh.med.osaka-u.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsImprovement in hepatic reserve after balloon-occluded retrograde transvenous obliteration (BRTO) in patients with gastric varices (GVs) has not been fully established. The relationship between increases in liver volume (LV) or splenic volume (SV) after BRTO and prognosis is still unclear. In this study, we aimed to evaluate the factors associated with improvement in hepatic reserve after BRTO in GV patients and the relationship between changes in LV or SV after BRTO and prognosis.

methodsWe retrospectively enrolled 258 patients who recieved their first BRTO for GV treatment at 12 institutions between January 2004 and May 2019. Hepatic reserve, LV, and SV were evaluated before and 6 months after BRTO.

resultsChanges in hepatic reserve were evaluated in 160 patients. Albumin levels and prothrombin time-international normalized ratio improved significantly, while platelet counts decreased significantly at 6 months after BRTO. Multivariate logistic regression analysis showed that history of hepatocellular carcinoma and modified albumin-bilirubin (mALBI) grade were independent factors associated with the improvement of albumin-bilirubin (ALBI) score. The ALBI score significantly improved in patients with mALBI grade 2b or 3 (p < 0.001), but not in patients with mALBI grade 1 or 2a. Eighty-three patients who underwent abdominal computed tomography examination 6 months after BRTO had significantly increased LV and SV (LV, p < 0.01; SV, p < 0.01). The patients with a > 10% increase in SV had significantly poorer prognosis than the others (p = 0.03).

conclusionsBRTO for GVs leads to improvement of hepatic reserve. Patients with increased SV after BRTO had poor prognosis.

trial registrationNot aplicable.

Indexed as

Balloon OcclusionEsophageal and Gastric VaricesLiverSpleenAgedBilirubinFemaleHumansMaleMiddle AgedOrgan SizePlatelet CountPrognosisProthrombin TimeRetrospective StudiesSerum AlbuminBilirubinSerum AlbuminBRTOHepatic reserveLiver volumeSpleen volume

Identifiers

PMID42067826
PMCPMC13289329

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.