Trial reportBMC oral health2026
Clinical evaluation of different bi-layer biomimetic strategies of composite resin in large class I cavities: an 18-month randomized clinical trial.
Trial report in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07285772 (Clinical Performance of Various Bilayer Biomimetic Resin Composite Strategies), which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Performance of Various Bilayer Biomimetic Resin Composite Strategies
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to conduct a randomized, double-blind, split-mouth comparative clinical trial to clinically assess and compare different bi-layer biomimetic strategies of composite resin in large class I cavities over an 18-month period. MATERIALS &
methodsA total of 160 posterior composite restorations in 40 participants of age 35-45 years old were enrolled in the study based on inclusion criteria. Each patient received four different bilayer biomimetic bases in four equal groups (n = 40) as follows: Group I: short-fiber reinforced composite (everX Posterior, GC Corporation, Tokyo, Japan); Group II: long-fiber reinforced composite (polyethylene fibers, Ribbond Inc., USA); Group III: Resin-Modified Glass Ionomer Cement (RMGIC) (Riva SDI, Bayswater, VIC, Australia); and Group IV: flowable composite (G-aenial universal Flo, GC Corp., Tokyo, Japan). A 2 mm surface layer of nanohybrid composite resin (Tetric Evo Ceram, Ivoclar Vivadent) was applied to cover the biomimetic base in all groups. Occlusal Class I cavities were prepared according to caries extension with a cavity depth of 4-5 mm. No bevels were prepared. Clinical assessment was carried out according to the World Dental Federation (FDI) by two calibrated evaluators at baseline and at 6, 12, and 18 months for aesthetic properties (surface and marginal staining), functional properties (fracture and retention, marginal adaptation), and biological properties (postoperative sensitivity, secondary caries). Statistical analysis employed Friedman and Kruskal-Wallis tests. The level of significance was established at α = 0.05 across all tests.
resultsForty patients with a total of 160 restorations were evaluated in line with FDI at the end of the study with 100% recall rates. No fracture or secondary caries was reported over an 18-month evaluation period. The intragroup (Friedman test) and intergroup (Kruskal-Wallis test) comparisons revealed no statistically significant differences among short fiber reinforced composite, long fiber reinforced composite, resin-modified glass ionomer cement, and flowable composite for the assessed criteria over time (p > 0.05).
conclusionAll tested bilayer biomimetic composite resins have comparable excellent short-term clinical performance by the end of the study period.
trial registrationThe protocol of the current study was approved by the Research Ethics Committee of the Faculty of Dentistry, Tanta University, Egypt, with approval number #R-RD-03-25-3194. This study was registered at www. CLINICALTRIALS: gov with the identification number NCT07285772 on 15/12/2025-'retrospectively registered.'
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.