ArticleBMC pregnancy and childbirth2026
Third-trimester maternal COVID-19 infection and oxidative stress biomarkers in umbilical cord blood.
Article in BMC pregnancy and childbirth, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundTo evaluate the effect of maternal COVID-19 infection on oxidative stress indicators in the umbilical cord.
methodsThis was a prospective study. The umbilical cord oxidative stress biomarkers, which include malondialdehyde (MDA), total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI), were compared between COVID-19 positive (study group) and COVID-19 negative mothers (control group).
resultsThere were 25 mothers in each group.Malondialdehyde, TOS, TAS, and OSI values were not associated with maternal age, delivery mode, gestational age, gender, anthropometric measurements, or APGAR scores.Malondialdehyde (26.97 nmol/L [11.14-46.88] vs. 9.93 nmol/L [7.33-13.40], p = 0.001) and TAS (2.13 ± 0.30 mmol/L vs. 1.93 ± 0.19 mmol/L, p = 0.005) values in the study group were significantly higher compared to the control group.The TOS and OSI were similar between the groups.
conclusionsMalondialdehyde and TAS were higher in the umbilical cord blood of COVID-19 positive mothers than in healthy controls during the third trimester. Third trimester maternal COVID-19 infection may be associated with increased oxidative stress, accompanied by a compensatory antioxidant response.
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