Evidence map›Paper›PMID 42067820›Full record

ArticleBMC public health2026

Individual and combined associations of modifiable metabolic health and lifestyle with low back pain, neck pain, and functional limitation: evidence from a nationally cross-sectional study.

Chengxin Xie, Qihang Li, Jingxin Xin, Xiao Jiang, Qiang He, Wenbo Bian, Dongting Yu, Yanru Lin, Zhenyu Yao

Abstract read
In one paragraph

Article in BMC public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Chengxin XieKey Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education;, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Qihang LiKey Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education;, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Jingxin XinKey Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education;, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Xiao JiangKey Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education;, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Qiang HeKey Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education;, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Wenbo BianKey Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education;, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Dongting YuSchool of Clinical and Basic Medicine, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Yanru LinSchool of Clinical and Basic Medicine, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Zhenyu YaoKey Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education;, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China. yaozhenyu@sdfmu.edu.cn.

Funding

Cultivation Plan of Shandong Provincial Hospital 2025PY201National Natural Science Foundation of China 82200879Noncommunicable Chronic Diseases-National Science and Technology Major Project 2023ZD0507800
6 · The paper itself

Abstract

backgroundAlthough healthy lifestyles are prioritized for the self-management of chronic low back pain (LBP) and neck pain (NP), the individual and combined associations of metabolic health and lifestyle with LBP, NP, and related functional limitations remain unclear. This study aimed to evaluate these associations and support risk stratification across different metabolic and lifestyle profiles.

methodsThis cross-sectional study used data from the US National Health and Nutrition Examination Survey (1999-2018) to analyze two cohorts: pain cohort (n = 10286) and functional limitation cohort (n = 28513). Metabolic factors included abdominal obesity, hyperglycemia, hypertension, and dyslipidemia. Lifestyle factors included smoking, alcohol consumption, diet, and physical activity. Outcomes, including LBP, NP, and back- or neck-related functional limitation (BN-FL), were assessed by self-reported questionnaires. Associations between risk factors and outcomes were assessed using multivariable logistic regression.

resultsIndividuals with poor metabolic-lifestyle status had the highest prevalence of LBP (42.6%), NP (21.4%), and BN-FL (17.6%). Physical inactivity showed the largest estimated population-attributable fraction (PAF) for LBP and NP (20.8% and 20.5%, respectively), while abdominal obesity (15.1%) and smoking (14.0%) showed the largest estimated PAFs for BN-FL. Poor metabolic status was associated with higher odds of LBP (OR = 1.470, 95% CI: 1.227-1.760) and BN-FL (OR = 2.404, 95% CI: 1.977-2.923), while poor lifestyle was associated with higher odds across all outcomes. Worsening lifestyle status was consistently associated with higher odds of LBP across all metabolic strata. The combination of poor metabolic-lifestyle status was associated with the highest odds of LBP (OR = 3.435, 95% CI: 2.026-5.824) and BN-FL (OR = 4.378, 95% CI: 2.347-8.167).

conclusionsBoth metabolic health and lifestyles were associated with LBP and BN-FL, while only lifestyles were linked to NP. Combined unfavorable metabolic and lifestyle profiles were associated with higher odds of LBP and BN-FL, underscoring the importance of both metabolic and lifestyle modification.

Indexed as

Life StyleLow Back PainNeck PainAdultCross-Sectional StudiesFemaleHumansMaleMiddle AgedNutrition SurveysRisk FactorsUnited StatesAmerican adultsFunctional limitationLifestyleLow back painMetabolic healthNeck pain

Identifiers

PMID42067820
PMCPMC13277017

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.