ArticleBMC genomics2026
Whole-genome sequencing of MDR K. pneumoniae circulating in Moroccan river ecosystems: a comprehensive genomic analysis of environmental isolates.
Article in BMC genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundKlebsiella pneumoniae is a major opportunistic pathogen and a recognized contributor to the global burden of antimicrobial resistance (AMR). Although traditionally associated with healthcare settings, it is increasingly detected in environmental compartments influenced by anthropogenic activities. Aquatic ecosystems may act as reservoirs and dissemination hubs for multidrug-resistant (MDR) lineages and resistance genes. However, genomic data on environmental K. pneumoniae in Morocco remain scarce. This pilot study aimed to characterize a targeted subset of MDR K. pneumoniae isolates recovered from Moroccan rivers using whole-genome sequencing (WGS), with a focus on resistance determinants, virulence-associated loci, plasmid content, and phylogenetic relationships.
resultsThe main findings revealed marked genetic heterogeneity among the environmental K. pneumoniae isolates. Of the 44 isolates recovered from six Moroccan rivers, 11 MDR isolates were selected for WGS and belonged to nine distinct sequence types, including the high-risk clones ST147 and ST307. Resistance to extended-spectrum β-lactams was mainly associated with ESBL genes, particularly bla
conclusionsThis pilot study provides the first whole-genome-based characterization of river-derived MDR K. pneumoniae in Morocco. It demonstrates that aquatic ecosystems harbor genetically diverse lineages carrying clinically relevant resistance and virulence determinants. These findings underscore the imperative of integrating environmental surveillance into national AMR monitoring strategies within a One Health framework.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.