ArticleOral and maxillofacial surgery2026
Bibliometric and science-mapping analysis of translation-oriented signals across six dental stem-cell subtypes: a Web of Science study (2000-2025).
Article in Oral and maxillofacial surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesTo benchmark publication growth, conceptual structure, and translation-oriented signals across six dental stem-cell (DSC) subtypes from 2000 to 2025.
methodsWeb of Science Core Collection (SCI-E/SSCI/ESCI) was searched (2000-2025) for DPSC, PDLSC, SHED, SCAP, DFSC, and GMSC records. After cross-subtype deduplication, corpus-level indicators and networks were computed on the deduplicated corpus (N = 13,327) using fractional assignment to avoid multi-subtype inflation. Subtype-level time trends were computed within each subtype export (full counting). Translation-oriented signals (biomaterials/scaffolds, in vivo models, EVs/exosomes, clinical-trial mentions) were estimated from a stratified random sample of 500 records per subtype (fixed seed 20251216) using rule-based dictionaries with manual verification of sampled classifications.
resultsOutput increased sharply after 2010 and spanned 1,462 journals. DPSC and PDLSC dominated publication volume, while SHED, SCAP, DFSC, and GMSC showed later growth. Science mapping resolved four recurring themes (regeneration applications; biomaterials/differentiation; angiogenesis/VEGF; immunomodulation/EVs). Across subtypes, biomaterials/scaffold and in vivo-model signals were frequent, EV/exosome signals rose after 2015, and clinical-trial mentions remained uncommon; SHED and GMSC showed comparatively higher EV/exosome and trial-mention proportions.
conclusionsThis subtype-resolved, overlap-aware evidence map provides a basis for comparative benchmarking and highlights where translational emphasis is increasing versus where clinical evidence remains sparse. CLINICAL RELEVANCE: These findings may help inform model selection, biomaterials strategy design, and prioritization of evidence gaps in regenerative dentistry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.